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JNCI：两microRNA力挽黑色素瘤转移之狂澜

2015-02-14 MedSci MedSci原创

microRNA黑色素瘤转移
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来自于纽约大学Langone医学中心及其Laura和Isaac Perlmutter肿瘤中心的研究人员，在被认为是迄今最大的对早期黑色素瘤细胞信号分子表观遗传分析的研究中，确定了在肿瘤中两个小的非编码基因材料与关键癌细胞的扩散的停滞相关，本质上影响着肿瘤的生物学命运。 在2月11日在线发表在Journal of the National Cancer Institute杂志上的一篇研究报告中

来自于纽约大学Langone医学中心及其Laura和Isaac Perlmutter肿瘤中心的研究人员，在被认为是迄今最大的对早期黑色素瘤细胞信号分子表观遗传分析的研究中，确定了在肿瘤中两个小的非编码基因材料与关键癌细胞的扩散的停滞相关，本质上影响着肿瘤的生物学命运。 在2月11日在线发表在Journal of the National Cancer Institute杂志上的一篇研究报告中，研究人员表示确定了这些所谓的“小分子核糖核酸”——名为miR-382和miR-516b，可以为未来医疗提供基础，以识别这些最容易传播的黑色素瘤并将其杀死。事实上，纽约大学Langone团队领导的这项研究已经开始后续临床研究，以查看是否有任何小分子核糖核酸有类似确定癌症的黑色素瘤患者的预后价值，预测肿瘤扩散到大脑的可能性。他们指出，黑素瘤患者将近一半的人死于肿瘤扩散到大脑。 小分子核糖核酸是表观遗传因子，是具有调控基因功能的DNA的化学近亲。但与其他种类的RNA不同，microRNA并不需要翻译成特定的蛋白质。 从对92名男性和女性的黑色素瘤患者肿瘤组织的分析中，发现了超过800种microR

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    2015-06-05 xjy02

    #Micro#

    0

  2. 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    2015-10-06 sunylz

    #色素#

    0

  3. 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    2015-06-18 lanyan20020086

    #NCI#

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Feb 16 12:58:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558686, encodeId=2d7a15586869e, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Mon Feb 16 12:58:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564695, encodeId=2d081564695a5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, 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    2015-05-16 ljjj1053

    很不错学习了

    0

  5. 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    2015-03-01 jiafufeng@yaho

    #CRO#

    0

  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Mon Feb 16 12:58:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-02-19 orthoW

    ?学习了

    0

  7. 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    2015-02-16 windmilL1989

    以阅

    0

  8. 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    2015-02-16 zhouqu_8

    #microRNA#

    0

  9. 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    2015-02-16 cqlidoudou

    #黑色素#

    0

  10. 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    2015-02-16 cqlidoudou

    #黑色素#

    0

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