PLoS Med:多不饱和脂肪酸与2型糖尿病(EPIC-InterAct研究)

2016-08-10 Seven L 译 MedSci原创

目的:探究n-3和n-6多不饱和脂肪酸(PUFA)与2型糖尿病(T2D)的关系。方法:使用气相色谱分析对12132名T2D和15919名对照组(来自在8个欧洲国家进行的欧洲癌症和营养的前瞻性调查(EPIC)相互作用研究(EPIC-InterAct))进行血浆磷脂PUFAs分析。对总的和国家特异性联系均进行了分析;此外还系统地回顾了已发表的有关PUFAs和T2D联系的前瞻性研究。结果:EPIC-In

目的:探究n-3和n-6多不饱和脂肪酸(PUFA)与2型糖尿病(T2D)的关系。方法:使用气相色谱分析对12132名T2D和15919名对照组(来自在8个欧洲国家进行的欧洲癌症和营养的前瞻性调查(EPIC)相互作用研究(EPIC-InterAct))进行血浆磷脂PUFAs分析。对总的和国家特异性联系均进行了分析;此外还系统地回顾了已发表的有关PUFAs和T2D联系的前瞻性研究。结果:EPIC-InterAct研究中,长链n-3 PUFAs、α-亚麻酸(ALA)与T2D呈负相关(每标准差[SD] HR 0.93; 95% CI 0.88-0.98);但是二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)与T2D无关。n-6 PUFAs中,亚油酸(LA)(0.80; 95% CI 0.77-0.83)和二十碳二烯酸(EDA) (0.89; 95% CI 0.85-0.94)与T2D呈负相关;花生四烯酸(AA)与T2D无关;γ-亚麻酸(GLA)、dihomo-GLA、二十二碳四烯酸(DTA)和二十二碳五烯酸(n6-DPA)与T2D呈正相关,每标准差[SD] HR在1.13到1.46之间。对研究

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    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-12 舒心和人

    不饱和脂肪酸对机体有利,有了数据的支持就更加相信了,学习了,感谢分享

    0

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    2016-08-16 Tomcat1984

    关于肉类肌纤维的研究发现,1型myhc,氧化型代谢,对胰岛素敏感,并倾向于囤积特定的脂肪酸。所以,数据相关性的本质,可能是肌纤维的类型组成。比如锻炼出更多的氧化型肌纤维,就能更有效地预防糖尿病(纯属个人观点,不喜勿喷)

    0

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