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J Food Sci:芦笋或可助缓解宿醉痛苦

2013-01-06 J Food Sci 搜狐科学 尚力

芦笋肝细胞宿醉
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宿醉是因过量饮酒导致的醉酒后状态，会伴随头痛、口渴、眩晕、胃病、恶心、呕吐、失眠、手颤和血压升高或降低等症状，带给人的痛苦不言而喻。美国食品科技学会（Institute of Food Technologists）在《食品科学》（Journal of Food Science）杂志上刊登了一份有关如何缓解宿醉痛苦的研究报告，报告称，芦笋提取物中发现的氨基酸和矿物质或能缓解宿醉痛苦，保护肝细胞免受毒


宿醉是因过量饮酒导致的醉酒后状态，会伴随头痛、口渴、眩晕、胃病、恶心、呕吐、失眠、手颤和血压升高或降低等症状，带给人的痛苦不言而喻。美国食品科技学会（Institute of Food Technologists）在《食品科学》（Journal of Food Science）杂志上刊登了一份有关如何缓解宿醉痛苦的研究报告，报告称，芦笋提取物中发现的氨基酸和矿物质或能缓解宿醉痛苦，保护肝细胞免受毒素侵害。

医学科学协会（Institute of Medical Science）和韩国济州国立大学（eju National University）的研究人员分析了芦笋嫩枝和叶子的成分，并将其作用于人体肝细胞的生物化学反应和作用于鼠肝细胞的生物化学反应进行了对比。首席研究员金姆（B.Y. Kim）表示：“叶子中发现的氨基酸和矿物质含量比嫩枝中发现的多。”

长期服用酒精会对肝造成氧化压力，并给人带来与宿醉有关的身体反应，如头痛、恶心等。金姆称：“让宿醉人士服用芦笋叶子和嫩枝提取物，我们发现其细胞毒性明显降低，这个结果为‘芦笋的生物学功能如何帮助减轻宿醉痛苦和保护肝细胞’提供了依据。”

芦笋是一种非常普遍的蔬菜，在全球各地都能买到。由于其独特的抗癌作用，芦笋一直被当作草药使用。除了抗癌外，它还有抗真菌、抗发炎和利尿的作用。



Effects of Asparagus officinalis Extracts on Liver Cell Toxicity and Ethanol Metabolism
ABSTRACT: Asparagus officinalis is a vegetable that is widely consumed worldwide and has also long been used as a herbal medicine for the treatment of several diseases. Although A. officinalis is generally regarded as a supplement for the alleviation of alcohol hangover, little is known about its effects on cell metabolism. Therefore, this study was conducted to analyze the constituents of the young shoots and the leaves of asparagus and to compare their biochemical properties. The amino acid and inorganic mineral contents were found to be much higher in the leaves than the shoots. In addition, treatment of HepG2 human hepatoma cells with the leaf extract suppressed more than 70% of the intensity of hydrogen peroxide (1 mM)-stimulated DCF fluorescence, a marker of reactive oxygen species (ROS). Cellular toxicities induced by treatment with hydrogen peroxide, ethanol, or tetrachloride carbon (CCl4) were also significantly alleviated in response to treatment with the extracts of A. officinalis leaves and shoots. Additionally, the activities of 2 key enzymes that metabolize ethanol, alcohol dehydrogenase and aldehyde dehydrogenase, were upregulated by more than 2-fold in response to treatment with the leaf- and shoot extracts. Taken together, these results provide biochemical evidence of the method by which A. officinalis exerts its biological functions, including the alleviation of alcohol hangover and the protection of liver cells against toxic insults. Moreover, the results of this study indicate that portions of asparagus that are typically discarded, such as the leaves, have therapeutic use.                 

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