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J Periodontol: 釉原蛋白肽的c末端对人骨髓间充质干细胞增殖的影响

2018-05-30 MedSci MedSci原创

釉原蛋白骨髓间充质干细胞增殖
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牙釉蛋白是牙釉质基质蛋白质家族，对牙釉质形成重要的。釉原蛋白可以诱导间充质干细胞（MSC）的分裂等。最近已显示，釉原蛋白肽（AMG-CP）的C-端可以增强成骨细胞谱系细胞的增殖。本实验研究了釉原蛋白肽对人MSCs增殖和细胞内信号传导途径相关改变的作用。

牙釉蛋白是牙釉质基质蛋白质家族，对牙釉质形成重要的。釉原蛋白可以诱导间充质干细胞（MSC）的分裂等。最近已显示，釉原蛋白肽（AMG-CP）的C-端可以增强成骨细胞谱系细胞的增殖。本实验研究了釉原蛋白肽对人MSCs增殖和细胞内信号传导途径相关改变的作用。

MSCs体外暴露于AMG-CP。使用MTS和5-溴-2'-脱氧尿苷（BrdU）测定来确定增殖情况。 Western blotting检测MSCs中釉原蛋白受体，溶酶体相关膜蛋白1（LAMP1）的表达。用抗LAMP1抗体抑制AMG-CP与LAMP1的结合。蛋白免疫印迹法和酶联免疫吸附试验研究丝裂原活化蛋白激酶（MAPK）-细胞外信号调节激酶（ERK）途径的组分，用U0126-MAPK抑制剂抑制ERK活性。

结果：在AMG-CP存在下MSC的增殖显着增强，并且可以被抗LAMP1抗体或U0126显着抑制。在AMG-CP存在下，磷酸化的ERK1 / 2增加，并且在抗-LAMP1抗体或U0126存在下，磷酸化的ERK1 / 2减少。

通过与LAMP1和MAPK-ERK信号传导途径的相互作用，C末端釉原蛋白变体增强了MSC的增殖作用，表明在颅面部使用MSC进行组织再生的可能性。

原始出处：

Kunimatsu R， et al. The C-terminus of the amelogenin peptide influences the proliferation of human bone marrow mesenchymal stem cell. Journal of Periodontology. 2018 April. doi：10.1002/JPER.17-0087

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    2018-08-21 feather89

    #PE#

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    2018-10-16 h.y200607_23674418

    #间充质干细#

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    2019-05-09 ying_wu

    #骨髓间充质干细胞#

    0

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    2019-03-02 tonychen33

    #釉原蛋白#

    0

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    2018-06-01 晓辰

    #细胞增殖#

    0

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    2018-05-31 惠映实验室

    学习了.谢谢分享.

    0

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    2018-05-30 zdvfsadb

    学习了

    0