J Endod:牙髓感染中存在念珠菌的发生率评估:系统性回顾和Meta分析

2018-10-10 lishiting MedSci原创

到目前为止,已有大量关于牙髓感染中念珠菌的研究报道,但是它作为牙髓致病菌的作用还饱受争议。这篇研究的目的是为了系统性的回顾文献中念珠菌属在根管感染中的检出率。

到目前为止,已有大量关于牙髓感染中念珠菌的研究报道,但是它作为牙髓致病菌的作用还饱受争议。这篇研究的目的是为了系统性的回顾文献中念珠菌属在根管感染中的检出率。

研究在最重要的电子生物医学数据库中进行大量的文献搜索,并且从相关文章的参考文献中进行额外的研究工作。使用Joanna Briggs Institute关键评估清单的修改版对研究内容进行严格评判。

结果显示,从2225条独立的记录中,通过题名和摘要的筛查排除了2118条。在剩下的107项研究中,全文回顾后又排除了50项,另57项进行了定性和定量的评估分析。感染根管内的整个念珠菌属检出率为8.20% (95% confidence interval, 5.56%-11.21%)。白色念珠菌是分离出来频率最高的种属。各项研究中存在显著的异质性(P < .001, I2 = 86.07%)。亚组分析显示,在非洲样本中念珠菌属的检出率更高。对所有研究进行严格的评判后,在8个项目中,有6个项目普遍存在较高或不明确的偏倚风险。

结论:念珠菌属在根管感染中发生比例较小。还需要更多更合理设计的研究来评估念珠菌属在感染根管中的微生物生态学作用。

原始出处

Mergoni G, Percudani D, et al. Prevalence of Candida Species in Endodontic Infections: Systematic Review and Meta-analysis. J Endod. 2018 Sep 18. pii: S0099-2399(18)30512-0. doi: 10.1016/j.joen.2018.07.016.

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    2019-06-14 guojianrong
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    2018-12-02 jxrzshh
  5. [GetPortalCommentsPageByObjectIdResponse(id=2017083, encodeId=75f2201e083a3, content=<a href='/topic/show?id=9760e69058c' target=_blank style='color:#2F92EE;'>#系统性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76905, encryptionId=9760e69058c, topicName=系统性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2b9b368, createdName=qingrejiedu, createdTime=Tue Aug 13 19:09:00 CST 2019, time=2019-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887944, encodeId=e9e8188e944c2, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Jun 14 11:09:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670599, encodeId=b3ad16e05998c, content=<a href='/topic/show?id=c0425209338' target=_blank style='color:#2F92EE;'>#念珠菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52093, encryptionId=c0425209338, topicName=念珠菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be826737448, createdName=tigerlr107, createdTime=Tue Feb 05 09:09:00 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669714, encodeId=fad81669e1491, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Sun Dec 02 19:09:00 CST 2018, time=2018-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1927341, encodeId=24b0192e3418e, content=<a href='/topic/show?id=5a4d6e672eb' target=_blank style='color:#2F92EE;'>#牙髓感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67672, encryptionId=5a4d6e672eb, topicName=牙髓感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=052a130, createdName=yyj062, createdTime=Sun Jul 28 19:09:00 CST 2019, time=2019-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896391, encodeId=8d3f18963912b, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Tue Oct 23 09:09:00 CST 2018, time=2018-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826480, encodeId=41b81826480a3, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Dec 02 16:09:00 CST 2018, time=2018-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348793, encodeId=3246348e9318, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Oct 10 21:32:39 CST 2018, time=2018-10-10, status=1, ipAttribution=)]
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    2018-10-23 一闲
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    2018-10-10 天地飞扬

    了解一下,谢谢分享!

    0

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