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Sci Rep：新型AGSA膜可有效促进伤口的愈合

2017-10-31 MedSci MedSci原创

AGSA伤口海藻酸钠
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随着耐药细菌和真菌病原体的出现，利用多种抗菌生物材料治疗急性损伤越来越受公众的关注。本研究中，研究人员制备了一种仿生银@还原型石墨烯-海藻酸钠（AGSA）复合膜可有效用于伤口的愈合。这种膜具有类似于珍珠层中典型的“实体”结构的层状微结构。在此珠母贝类似物结构中，纳米片和聚合物基体之间存在丰富的界面相互作用，从而可显著增强强度。研究结果表明，与纯海藻酸钠膜相比，拉伸强度、韧性和杨氏模量分别提高了2.

随着耐药细菌和真菌病原体的出现，利用多种抗菌生物材料治疗急性损伤越来越受公众的关注。本研究中，研究人员制备了一种仿生银@还原型石墨烯-海藻酸钠（AGSA）复合膜可有效用于伤口的愈合。这种膜具有类似于珍珠层中典型的“实体”结构的层状微结构。在此珠母贝类似物结构中，纳米片和聚合物基体之间存在丰富的界面相互作用，从而可显著增强强度。

研究结果表明，与纯海藻酸钠膜相比，拉伸强度、韧性和杨氏模量分别提高了2.8、2.3和2.7倍。在伤口愈合研究中，AGSA膜对铜绿假单胞菌、大肠杆菌和白色念珠菌显示出有效的抗菌活性，表明其在保护伤口免受致病微生物感染的能力。。

此外，大鼠体内实验表明，AGSA膜可促进创面恢复。MTT实验、溶血评价和体内毒性评价表明复合膜是一种良好的生物相容性材料。

总之，该研究而结果表明，这种AGSA膜可很好地促进伤口的愈合，具有在组织工程中应用的潜力。

原始出处：

Xu Yan, Fei Li, Kang-Di Hu, et al., Nacre-mimic Reinforced Ag@reduced Graphene Oxide-Sodium Alginate Composite Film for Wound Healing. Sci Rep. 2017; 7: 13851. Published online 2017 Oct 23. doi: 10.1038/s41598-017-14191-5

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    2018-02-22 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2018-03-30 12498f17m77暂无昵称

    #AGS#

    0

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    2017-11-01 飛歌

    学习了很有用

    0

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    2017-10-31 惠映实验室

    学习了.谢谢

    0

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    2017-10-31 thlabcde

    好资料学习了!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=289947, encodeId=068528994e8b, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Feb 22 14:55:37 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1741312, encodeId=18c01e4131287, content=<a href='/topic/show?id=755321140e' target=_blank style='color:#2F92EE;'>#AGS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2114, encryptionId=755321140e, topicName=AGS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b9034929696, createdName=12498f17m77暂无昵称, createdTime=Fri Mar 30 21:42:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257640, encodeId=b25125e640b0, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Wed Nov 01 00:21:17 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257602, encodeId=f33325e602f6, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Oct 31 22:02:08 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257584, encodeId=815a25e584c5, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Oct 31 21:47:26 CST 2017, time=2017-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257577, encodeId=24ce25e5770f, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Oct 31 21:45:38 CST 2017, time=2017-10-31, status=1, ipAttribution=)]
    2017-10-31 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0