Thorax:外周血白细胞端粒长度与系统性硬化症间质性肺病进展相关

2021-07-21 MedSci原创 MedSci原创

这些结果表明端粒功能障碍可能与SSc-ILD进展相关,并且PBL-TL测量可能有助于对SSc-ILD进展风险进行分层。

外周血白细胞端粒长度(PBL-TL)与特发性肺纤维化患者的预后相关。PBL-TL是否与系统性硬化症相关的间质性肺病(SSc-ILD)进展相关尚未明确。

近日,胸部疾病领域权威杂志Thorax上发表了一篇研究文章,这项回顾性观察性队列研究使用加州大学旧金山分校(UCSF)硬皮病中心前瞻性收集地213名SSc患者数据进行分析。PBL-TL通过对从外周血中分离的DNA进行定量PCR来确定。

研究人员使用广义线性混合模型通过纵向分析评估了SSc-ILD患者PBL-TL与肺功能测试趋势之间的关联。这些研究结果在斯坦福大学硬皮病中心数据库登记的61名SSc-ILD患者队列进行了验证。

研究人员发现伴有ILD的UCSFSSc患者PBL-TL比不伴有ILD的患者要短(6554±671(碱基对,bp) vs. 6782±698bp, p=0.01)。较短的PBL-TL与ILD相关(TL减少1000 bp调整后的OR为2.1,95%CI为[1.25至3.70],p=0.006)。与血清阳性受试者相比,缺乏SSc特异性自身抗体的SSc-ILD患者PBL-TL较短(6237±647bp vs. 6651±653bp,p=0.004)。更短的PBL-TL与肺功能恶化风险增加相关,在合并的SSc-ILD队列中,PBL-TL每减少1000bp,肺功能每年平均损失增加67mL(纵向分析,调整模型:95%CI为-104mL至-33mL,p<0.001)。

由此可见,这些结果表明端粒功能障碍可能与SSc-ILD进展相关,并且PBL-TL测量可能有助于对SSc-ILD进展风险进行分层。

原始出处:

Shuo Liu,et al.Peripheral blood leucocyte telomere length is associated with progression of interstitial lung disease in systemic sclerosis.Thorax.2021.https://thorax.bmj.com/content/early/2021/07/15/thoraxjnl-2020-215918

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    2021-09-28 amy0559
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    2021-07-22 ms3000001999514966

    理学系统

    0

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