JAHA:无细胞线粒体DNA可作为宇航员健康的潜在生物标志物

2021-10-20 MedSci原创 MedSci原创

无细胞线粒体DNA丰度可能是太空飞行过程中与微重力、辐射和其他环境因素相关的压力或免疫反应的生物标志物。

据报道,宇航员在国际空间站上进行了短期和长期任务后,会遇到与太空旅行相关的压力因素,例如微重力或辐射暴露。尽管采取了降低风险的策略,但不良健康影响仍然是目前需要解决的难题。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在开发新的诊断工具以促进生理应激的早期检测。

研究人员在发射前10天、着陆当天和返回后3天测量了14名宇航员循环血浆中无细胞线粒体DNA的水平。

研究人员的结果发现,在着陆当天和太空返回后3天,血浆中的无细胞线粒体DNA水平显著增加,宇航员间约伴有2至355倍的变异性。此外,外周血单个核细胞的基因表达分析发现炎症、氧化应激和DNA损伤的标志物显著增加。

该研究的结果表明,无细胞线粒体DNA丰度可能是太空飞行过程中与微重力、辐射和其他环境因素相关的压力或免疫反应的生物标志物。

原始出处:

Malik Bisserier.et al.Cell‐Free Mitochondrial DNA as a Potential Biomarker for Astronauts' Health.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.022055

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    2021-10-22 zhaohui6731
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    2021-10-21 呼吸科小医生

    好好学习,天天向上

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1804714, encodeId=f1d91804e14c5, content=<a href='/topic/show?id=5b5de757587' target=_blank style='color:#2F92EE;'>#线粒体DN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77575, encryptionId=5b5de757587, topicName=线粒体DN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Mon Aug 15 05:01:00 CST 2022, time=2022-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841756, encodeId=db5c1841e567c, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Jan 22 11:01:00 CST 2022, time=2022-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2037853, encodeId=7a6a203e853b7, content=<a href='/topic/show?id=08c8456e93b' target=_blank style='color:#2F92EE;'>#宇航员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45679, encryptionId=08c8456e93b, topicName=宇航员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Fri Apr 01 14:01:00 CST 2022, time=2022-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268650, encodeId=30d61268650f5, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Oct 22 11:01:00 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419796, encodeId=be5f1419e966a, content=<a href='/topic/show?id=1617e7576fd' target=_blank style='color:#2F92EE;'>#线粒体DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77576, encryptionId=1617e7576fd, topicName=线粒体DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=427c3531901, createdName=jambiya, createdTime=Fri Oct 22 11:01:00 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561081, encodeId=546c156108107, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Oct 22 11:01:00 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567090, encodeId=0aa8156e09091, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Oct 22 11:01:00 CST 2021, time=2021-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062470, encodeId=8fd110624e0a2, content=好好学习,天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210612/4cac76eb29134c3aa63a2560971ec878/648fa1cb22cd430380c051eb0a8f6259.jpg, createdBy=7a8d5519826, createdName=呼吸科小医生, createdTime=Thu Oct 21 07:39:02 CST 2021, time=2021-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1062369, encodeId=22d1106236920, content=不错,有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca432042642, createdName=lemon985, createdTime=Wed Oct 20 20:25:38 CST 2021, time=2021-10-20, status=1, ipAttribution=)]
    2021-10-20 lemon985

    不错,有意思

    0

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