J Periodontol: 慢性和侵袭性牙周炎患者牙龈组织中干扰素-λ的表达

2018-05-30 MedSci MedSci原创

一些研究已经证明慢性和侵袭性牙周炎患者牙周袋中存在疱疹病毒。最近发现,干扰素λ(IFN-λ)具有抗病毒特性并且由疱疹病毒诱导。本研究旨在定量分析慢性和侵袭性牙周炎患者牙龈组织中IFN-λs(IFN-λ1,IFN-λ2,IFN-λ3)的mRNA表达。

一些研究已经证明慢性和侵袭性牙周炎患者牙周袋中存在疱疹病毒。最近发现,干扰素λ(IFN-λ)具有抗病毒特性并且由疱疹病毒诱导。本研究旨在定量分析慢性和侵袭性牙周炎患者牙龈组织中IFN-λs(IFN-λ1,IFN-λ2,IFN-λ3)的mRNA表达。

共有90名参与者(男性50名,女性40名;19?50岁,平均年龄31.50±7.8)分为健康参与者,慢性牙周炎患者和侵袭性牙周炎患者三组。用逆转录聚合酶链反应评估牙龈组织中IFN-λs的mRNA表达,并与牙龈指数(GI),探诊深度(PPD)和临床附着水平(CAL)等临床参数相关。

结果:在健康受试者,慢性和侵袭性牙周炎患者的牙龈组织中表达IFN-λ1,IFN-λ2和IFN-λ3的mRNA。在侵袭性牙周炎中IFN-λ1(3.049±9.793)水平最高,而在慢性牙周炎中IFN-λ2(4.322±11.310)和IFN-λ3(11.932±27.479)最高。 IFN-λ1(p = 0.008)和IFN-λ3(p = 0.043)在三组间的mRNA表达差异有统计学意义。

慢性和侵袭性牙周炎患者中IFN-λ升高提示其在牙周炎中的作用。需要进一步评估牙周炎患者IFN-λ1和IFN-λ3表达的变化。牙龈组织中抗病毒IFN-λs的mRNA表达可能会加强我们对牙周病病毒发病机制的理解。

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    2018-10-23 feather89
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    2018-06-01 sunyl07
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    2018-05-30 虈亣靌

    了解一下.谢谢分享!

    0

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