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Diabetologia：空腹血糖、体重指数、年龄和性别对全因死亡的复杂相互作用:对1500万韩国成年人的队列研究

2020-11-30 MedSci原创 MedSci原创

年龄；性别对全因死亡
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这项工作的目的是检查BMI和空腹血糖(FBG)是否与死亡率存在协同关系，并确定按性别和年龄划分的高死亡率的FBG - BMI联合亚群。

这项工作的目的是检查BMI和空腹血糖(FBG)是否与死亡率存在协同关系，并确定按性别和年龄划分的高死亡率的FBG - BMI联合亚群。

在2003年至2006年期间，共有15 149,275名韩国成年人参加了健康检查，并随访到2018年12月。采用Cox比例危险模型评估40组FBG-BMI联合组的死亡率HRs。

在平均13.7年的随访中，有1，213，401人死亡。在FBG和所有体重指数类别的全因死亡率之间发现了一个J型关联。在任何给定的FBG水平下，体重指数< 20 kg/m2的人死亡率最高，其次是体重指数为20-22.4 kg/m2的人。与肥胖个体相比，瘦个体FBG值升高的不利影响更大。此外，高血糖和消瘦的协同副作用在年轻人中比在老年人中更强。与参考组(体重超标且血糖正常)相比，体重超标且血糖正常(体重指数< 20kg/m2和FBG 4.4-5.2毫摩尔/升)、体重超标且患有糖尿病(体重指数25-27.4kg/m2和FBG ≥10.0毫摩尔/升)和体重超标且患有糖尿病(体重指数< 20kg/m2和FBG ≥10.0毫摩尔/升)的人的经年龄和性别调整的心率分别为1.29、2.59和11.18与死亡率较高相关的体重指数-FBG亚组的识别并不直接，FBG 6.1-6.9毫摩尔/升和体重指数20-22.4千克/平方米的组与FBG 7.0-9.9毫摩尔/升和体重指数≥22.5千克/平方米的组相比，死亡率相似或更高。在年龄< 45岁、FBG值< 6.9毫摩尔/升的女性中，体重指数≥27.5 kg/m2的女性死亡率最高，而体重指数< 20 kg/m2的个体在其他年龄组和性别组中的死亡率最高。

消瘦和高血糖相互作用，以超倍增的方式增加死亡率，特别是在年轻人中；体重指数、FBG、性别和年龄与死亡率之间的相互作用是复杂的。

原始出处：

Mi-Hyang Jung, Sang-Wook Yi,Complex interaction of fasting glucose, body mass index, age and sex on all-cause mortality: a cohort study in 15 million Korean adults

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    2021-11-14 hb2008ye

    #相互作用#

    0

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    2021-09-09 ms5439512287675881

    #BET#

    0

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    2021-01-01 智者为医08

    #DIA#

    0

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    2020-12-02 手留余香

    #空腹血糖#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1909305, encodeId=05031909305bb, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Nov 14 02:53:09 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761550, encodeId=1b161e6155015, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Sep 09 22:53:09 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639669, encodeId=33bb1639669e2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jan 01 17:53:09 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304994, encodeId=747913049948b, content=<a href='/topic/show?id=1970e539018' target=_blank style='color:#2F92EE;'>#空腹血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75390, encryptionId=1970e539018, topicName=空腹血糖)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Wed Dec 02 11:53:09 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334901, encodeId=152a13349018f, content=<a href='/topic/show?id=d16910002215' target=_blank style='color:#2F92EE;'>#韩国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100022, encryptionId=d16910002215, topicName=韩国)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Wed Dec 02 11:53:09 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471670, encodeId=abcf14e1670d9, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Wed Dec 02 11:53:09 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904008, encodeId=e2ff90400844, content=韩国数据很有参考价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Tue Dec 01 21:07:10 CST 2020, time=2020-12-01, status=1, ipAttribution=)]
    2020-12-02 zjshifan_98647306

    #韩国#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1909305, encodeId=05031909305bb, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Nov 14 02:53:09 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761550, encodeId=1b161e6155015, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Sep 09 22:53:09 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639669, encodeId=33bb1639669e2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jan 01 17:53:09 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304994, encodeId=747913049948b, content=<a href='/topic/show?id=1970e539018' target=_blank style='color:#2F92EE;'>#空腹血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75390, encryptionId=1970e539018, topicName=空腹血糖)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Wed Dec 02 11:53:09 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334901, encodeId=152a13349018f, content=<a href='/topic/show?id=d16910002215' target=_blank style='color:#2F92EE;'>#韩国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100022, encryptionId=d16910002215, topicName=韩国)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Wed Dec 02 11:53:09 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471670, encodeId=abcf14e1670d9, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Wed Dec 02 11:53:09 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904008, encodeId=e2ff90400844, content=韩国数据很有参考价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Tue Dec 01 21:07:10 CST 2020, time=2020-12-01, status=1, ipAttribution=)]
    2020-12-02 ylz8405

    #互作#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1909305, encodeId=05031909305bb, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Nov 14 02:53:09 CST 2021, time=2021-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761550, encodeId=1b161e6155015, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Sep 09 22:53:09 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639669, encodeId=33bb1639669e2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Jan 01 17:53:09 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304994, encodeId=747913049948b, content=<a href='/topic/show?id=1970e539018' target=_blank style='color:#2F92EE;'>#空腹血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75390, encryptionId=1970e539018, topicName=空腹血糖)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Wed Dec 02 11:53:09 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334901, encodeId=152a13349018f, content=<a href='/topic/show?id=d16910002215' target=_blank style='color:#2F92EE;'>#韩国#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100022, encryptionId=d16910002215, topicName=韩国)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Wed Dec 02 11:53:09 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471670, encodeId=abcf14e1670d9, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Wed Dec 02 11:53:09 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904008, encodeId=e2ff90400844, content=韩国数据很有参考价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210315/480e12f811f44bc39b347d2521d56e86/67d0e6d503124ea685205b567af3dffd.jpg, createdBy=f9435296193, createdName=Baodongxu, createdTime=Tue Dec 01 21:07:10 CST 2020, time=2020-12-01, status=1, ipAttribution=)]
    2020-12-01 Baodongxu

    韩国数据很有参考价值

    0