PNAS:慢性疲劳综合征生物标记物被发现

2017-08-02 海北 MedSci原创

肌痛性脑脊髓炎或慢性疲劳综合征是一种病因未知的复杂疾病。在美国,该病的发病人数在一百万以上,而在全球,该疾病有数百万患者。之前的报导显示,肌痛脑脊髓炎或慢性疲劳综合征患者有炎症的迹象,但是现有的数据量非常有限,且相互矛盾。

肌痛性脑脊髓炎或慢性疲劳综合征是一种病因未知的复杂疾病。在美国,该病的发病人数在一百万以上,而在全球,该疾病有数百万患者。之前的报导显示,肌痛脑脊髓炎或慢性疲劳综合征患者有炎症的迹象,但是现有的数据量非常有限,且相互矛盾。 来自斯坦福大学的研究人员利用高通量的方法,测试了人类免疫系统中多个炎症标记物。为了确定血清中的细胞因子能否和肌痛性脑脊髓炎或慢性疲劳综合征的发生,疾病的严重程度和持续时间相关,研究人员检测了192名肌痛性脑脊髓炎或慢性疲劳综合征患者以及392名健康人的细胞因子。每个细胞因子的预处理数据都利用疾病的严重程度,年龄,性别,种族和非特异性结合进行了回归。 研究人员发现,和健康人相比,肌痛性脑脊髓炎或慢性疲劳综合征患者的TGF-β含量升高(P = 0.0052),而抵抗素含量降低(P = 0.0052)。此外,有17个细胞因子在肌痛性脑脊髓炎或慢性疲劳综合征患者中随着疾病的严重程度呈现显著的上升趋势,它们是CCL11(Eotaxin-1),CXCL1(GROα),CXCL10(IP-10),IFN-γ,IL-4,IL-5,IL-7,IL-12p70,IL-13,IL-17F

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    2018-06-25 wjywjy
  3. 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    2017-09-12 drwjr
  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Thu Aug 03 04:35:50 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229138, encodeId=296722913818, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Aug 02 11:03:46 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2017-08-06 139****9672

    学习了,继续努力

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Thu Aug 03 04:35:50 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229138, encodeId=296722913818, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Aug 02 11:03:46 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2017-08-03 tamgche
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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Thu Aug 03 04:35:50 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229138, encodeId=296722913818, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Aug 02 11:03:46 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2017-08-03 lou.minghong

    学习了谢谢分享!

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Thu Aug 03 04:35:50 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229138, encodeId=296722913818, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Aug 02 11:03:46 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2017-08-02 天涯183

    非常好的文章,学习了,很受益

    0

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