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J Biomed Mater Res B Appl Biomater：干细胞复合水凝胶伤口敷料可促进伤口愈合和皮肤再生

2018-04-11 MedSci MedSci原创

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在该研究中，研究人员使用小鼠和猪模型研究了明胶基水凝胶（GBH）伤口敷料联合脂肪源性干细胞（ADSC）在伤口愈合中的效果。 体外研究结果显示，与从小鼠获得的ADSCs相比，从猪获得的ADSCs可显著增加细胞生长并促进细胞分化（脂肪形成和骨生成）。 此外，体内结果也表明，GBH伤口敷料联合ADSCs及其培养基可以加速小鼠和猪模型中的伤口愈合。ADSCs提供了通过皮肤再生从伤口和损伤中恢复的可能性。

在该研究中，研究人员使用小鼠和猪模型研究了明胶基水凝胶（GBH）伤口敷料联合脂肪源性干细胞（ADSC）在伤口愈合中的效果。

体外研究结果显示，与从小鼠获得的ADSCs相比，从猪获得的ADSCs可显著增加细胞生长并促进细胞分化（脂肪形成和骨生成）。 此外，体内结果也表明，GBH伤口敷料联合ADSCs及其培养基可以加速小鼠和猪模型中的伤口愈合。ADSCs提供了通过皮肤再生从伤口和损伤中恢复的可能性。

因此，体外和体内结果都表明，ADSCs可能通过GBH伤口敷料进行有效的临床治疗，这是一种很有前景的用于皮肤再生的补充和替代药物。

原始出处：

Hsu LC, Peng BY, et al., The potential of the stem cells composite hydrogel wound dressings for promoting wound healing and skin regeneration: In vitro and in vivo evaluation. J Biomed Mater Res B Appl Biomater. 2018 Mar 26. doi: 10.1002/jbm.b.34118.

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    2018-04-19 sunylz

    #Bio#

    0

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    2018-07-03 guozhenyu

    #敷料#

    0

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    2018-04-13 tastas

    #水凝胶#

    0

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    2018-04-13 chenzhuanggui

    #伤口愈合#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1918025, encodeId=a6e819180251f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Apr 19 03:42:00 CST 2018, time=2018-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634633, encodeId=d1be163463369, content=<a href='/topic/show?id=91f85e855f2' target=_blank style='color:#2F92EE;'>#敷料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57855, encryptionId=91f85e855f2, topicName=敷料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=362922222105, createdName=guozhenyu, createdTime=Tue Jul 03 04:42:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308014, encodeId=b4b0130801449, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Apr 13 13:42:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309871, encodeId=df2813098e18a, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Apr 13 13:42:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460960, encodeId=8f501460960d9, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Apr 13 13:42:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608735, encodeId=7b621608e3544, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Apr 13 13:42:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304920, encodeId=edbb304920bf, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Apr 12 00:03:11 CST 2018, time=2018-04-12, status=1, ipAttribution=)]
    2018-04-13 lishizhe

    #凝胶#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1918025, encodeId=a6e819180251f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Apr 19 03:42:00 CST 2018, time=2018-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634633, encodeId=d1be163463369, content=<a href='/topic/show?id=91f85e855f2' target=_blank style='color:#2F92EE;'>#敷料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57855, encryptionId=91f85e855f2, topicName=敷料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=362922222105, createdName=guozhenyu, createdTime=Tue Jul 03 04:42:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308014, encodeId=b4b0130801449, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Apr 13 13:42:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309871, encodeId=df2813098e18a, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri Apr 13 13:42:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460960, encodeId=8f501460960d9, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Apr 13 13:42:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608735, encodeId=7b621608e3544, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Apr 13 13:42:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304920, encodeId=edbb304920bf, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Apr 12 00:03:11 CST 2018, time=2018-04-12, status=1, ipAttribution=)]
    2018-04-13 ms3994565386320060

    #Med#

    0

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    2018-04-12 飛歌

    学习了很有用

    0