Heart:Covid-19患者急性心肌损伤常见且与不良预后相关

2020-06-12 MedSci原创 MedSci原创

急性心肌损伤在Covid-19患者中较为常见,并与不良预后相关。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在评估中国武汉以外地区Covid-19患者急性心肌损伤患病率及其直接的临床意义。

研究人员前瞻性地评估了中国四川两个指定的Covid-19治疗中心就诊的患者病历、实验室结果、胸部CT图像和用药情况。感兴趣的结局包括死亡、重症监护病房(ICU)入院、需要机械通气、使用血管活性药物治疗以及疾病严重性分类。急性心肌损伤的定义是高敏感性肌钙蛋白T(hs-TnT)值大于正常上限。

2020年1月至2020年3月10日期间共有101例病例,平均年龄为49岁,IQR为34-62岁。15.8%的患者存在急性心肌损伤,其中将近一半的患者hs-TnT值是正常上限的五倍。急性心肌损伤患者年龄较大,既往心血管疾病患病率更高,更可能需要接受ICU入院(62.5% vs. 24.7%,p=0.003)、机械通气(43.5% vs. 4.7%,p<0.001)和血管活性剂治疗(31.2% vs. 0%,p<0.001)。hs-TnT对数与疾病严重程度相关(OR为6.63,95%CI为2.24至19.65),所有三例死亡均发生在急性心肌损伤患者中。

由此可见,急性心肌损伤在Covid-19患者中较为常见,并与不良预后相关。

原始出处:

Feifei Bu.et al.Longitudinal associations between loneliness, social isolation and cardiovascular events.heart.2020.https://heart.bmj.com/content/early/2020/05/26/heartjnl-2020-316614

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    2020-06-14 zhaojie88
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    2020-06-14 slcumt
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