J Cosmet Dermatol:外用乙酰锌酮可有效改善光老化损伤

2021-08-21 MedSci原创 MedSci原创

乙酰姜酮(AZ)是来自姜的植物化学物质姜酮的衍生物,是一种新型化合物,据称具有抗衰老特性。发表于J Cosmet Dermatol的随机试验评估了乙酰姜酮在改善面部皮肤皱纹、发红、色素沉着和光老化方面

乙酰姜酮(AZ)是来自姜的植物化学物质姜酮的衍生物,是一种新型化合物,据称具有抗衰老特性。发表于J Cosmet Dermatol的随机试验评估了乙酰姜酮在改善面部皮肤皱纹、发红、色素沉着和光老化方面的作用。

研究纳入31名健康的参与者(年龄为44±7岁),以盲法方式随机分配到全脸涂抹1%的AZ或安慰剂(由载体基底霜组成),每天两次,共3次访问。使用面部图像分析摄影和软件评估光老化的迹象,包括皱纹、色素沉着和发红。

 

结果显示,与安慰剂相比,AZ组的平均皱纹严重程度(P=0.019;平均值=25.7%的变化)、总皱纹量(P=0.003;平均值=30.1%的变化)、色素强度(P=0.021;平均值=25.6%的变化)和发红强度(P=0.035;平均值=20.7%的变化)在8周内有明显下降。没有出现明显的瘙痒、燃烧或刺痛。两组在临床评估中的脱屑、红斑、色素沉着或色素沉着方面也没有明显的差异。

综上,该研究结果表明,与安慰剂相比,外用AZ可改善光损伤,减少皱纹、色素沉着和红肿强度的出现。乙酰锌酮在日常使用中具有良好的耐受性。

 

原始出处:

 

Simran Dhaliwal, et al., Randomized double-blind vehicle controlled study of the effects of topical acetyl zingerone on photoaging. J Cosmet Dermatol. 2021 Jan;20(1):166-173. doi: 10.1111/jocd.13464.  

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    2021-11-11 tcm99hq
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    2022-01-29 一闲
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