Diabetes Care:2型糖尿病患者适度饮酒或有益于心血管

2014-03-07 cath 编译 医学论坛网

一项多国联合研究表明,适度饮酒(尤其是葡萄酒)的2型糖尿病患者与心血管事件或全因死亡风险降低有相关性。研究由乔治全球健康研究院牵头,相关论文2月27日在线发表于《糖尿病护理》(Diabetes Care)杂志。 适度饮酒与死亡和冠状动脉疾病风险减少具有相关性,而2型糖尿病患者的心血管健康和饮酒的相关性尚未明了。该研究的研究者们评估了ADVANCE试验参与者饮酒带来的影响。主要终点为心血管事件(心

一项多国联合研究表明,适度饮酒(尤其是葡萄酒)的2型糖尿病患者心血管事件或全因死亡风险降低有相关性。研究由乔治全球健康研究院牵头,相关论文2月27日在线发表于《糖尿病护理》(Diabetes Care)杂志。【原文下载】

适度饮酒与死亡和冠状动脉疾病风险减少具有相关性,而2型糖尿病患者的心血管健康和饮酒的相关性尚未明了。该研究的研究者们评估了ADVANCE试验参与者饮酒带来的影响。主要终点为心血管事件(心血管死亡、心肌梗死和卒中)、微血管并发症和全因死亡。

结果显示,在中位随访5年期间,1031例患者(9%)死亡,1147例(10%)发生心血管事件,1136例(10%)发生微血管并发症。

与自报不饮酒的患者相比,报告适度饮酒者心血管事件发生较少[校正风险比(aHR) 0.83,P=0.008]、微血管并发症较少(aHR 0.85,P=0.03),且全因死亡率较低(aHR 0.87,P=0.05)。上述益处在饮葡萄酒为主的参与者中尤为明显。与自报不饮酒的患者相比,报告大量饮酒者的心血管事件和全因死亡风险呈饮酒量依赖性升高。

文章的第一作者,乔治全球健康研究院和悉尼大学的副教授Graham Hillis表示,这项研究提供了证据证明了适度饮用葡萄酒的2型糖尿病患者比那些完全不饮酒的2型糖尿病患者具有更低的心脏病风险。但他也提醒大家,这项研究只能说明饮酒的人具有更低的心脏病风险,并不能证明饮酒可以降低风险。

Hillis教授还表示,在考虑饮用葡萄酒的潜在好处时,也需要衡量可能带来的负面效果,饮用葡萄酒可能会增加低血糖风险、肝脏相关的并发症和某些癌症的发病率。

澳大利亚糖尿病理事会的认证执业营养师Lamees Kaoutarani表示,该研究的结果非常有趣,她希望看到进一步的研究结果。澳大利亚糖尿病理事会支持适度饮酒,每天不超过两杯,但是她也提醒大家,不要将这个数据理解为这是降低心血管疾病风险的最佳方案。Kaoutarani女士还说:“酒精具有高卡路里,可能导致体重和高甘油三酯水平的升高,并增加和糖尿病相关并发症的风险”。Kaoutarani女士建议,糖尿病患者应继续结合健康饮食、日常锻炼和适当的糖尿病管理来减少心脑血管疾病的危险。

原始出处:

Blomster JI1, Zoungas S, Chalmers J, Li Q, Chow CK, Woodward M, Mancia G, Poulter N, Williams B, Harrap S, Neal B, Patel A, Hillis GS.The Relationship Between Alcohol Consumption and Vascular Complications and Mortality in Individuals With Type 2 Diabetes Mellitus.Diabetes Care. 2014 Feb 27.【原文下载】


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