JAMA Neurol:脑卒中复发临床特点、诱因及危险因素

2017-08-12 zhangfan MedSci原创

研究阐述了脑卒中以及相关功能障碍复发特征,该研究将有利于脑卒中复发的临床诊断以及与短暂性脑缺血发作、偏头痛、托德瘫痪和乌托夫现象的区别。下一步应采用前瞻性研究以验证相关特征并解释潜在的机制

卒中后功能障碍复发或脑卒中复发(PSR)的临床特征尚未被完全阐述。近日研究人员就脑卒中复发的临床特点、诱因及危险因素进行了探讨。

本研究为回顾性研究,包含交叉队列研究和病例对照研究,使用2000-2015年间马萨诸塞州总医院数据库资料。患者确诊为脑血管疾病,接受至少一次的脑磁共振成像,存在长期复发可能。总共153名患者初步符合脑卒中复发或相关功能障碍复发诊断标准:残余脑卒中后局灶性神经功能缺损或既往卒中相关的局灶性神经功能缺损的瞬态复发或短暂恶化、入院磁共振成像显示慢性中风、无急性梗死或出血、 无短暂性脑缺血发作或发作的证据、弥散加权成像无急性损害、无临床或脑电图确证的时间发作证据。研究的主要终点是确证PSR临床和影像学特征、诱发以及风险因素。

共153名患者参与研究,其中梗塞史患者145人,高血压脑出血8人。患者平均年龄67岁,60%为女性。平均在首次中风后3.9年发生复发,持续时间18.4小时,其中69%的复发患者在发病1天内得到处置。功能障碍复发通常是突然的,轻微的,主要影响运动感觉或语言功能,无凝视麻痹、偏盲或忽视现象;脑卒中复发期间,NIHSS平均分数恶化2.5分,38%的功能障碍复发存在单一的NIHSS指征;慢性中风患者脑磁共振表象主要是集中于白质纤维束,73%的患者存在大脑中动脉区病变;感染、低血压、低钠血症、失眠、压力和苯二氮卓类药物易引发脑出血复发;女性、非洲及少数裔患者脑出血复发概率较大;复发患者常伴有糖尿病、血脂异常、吸烟、小血管梗塞;4%的患者静脉注射组织纤溶酶原激活剂无并发症。

研究阐述了脑卒中以及相关功能障碍复发特征,该研究将有利于脑卒中复发的临床诊断以及与短暂性脑缺血发作、偏头痛、托德瘫痪和乌托夫现象的区别。下一步应采用前瞻性研究以验证相关特征并解释潜在的机制。

原始出处:


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    2018-07-09 yinhl1978
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createdTime=Sun Aug 13 08:31:24 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232929, encodeId=d7c4232929d9, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Aug 12 19:52:35 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-30 虈亣靌

    不错的.学习了.谢谢分享!

    0

  4. 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createdTime=Sun Aug 13 08:31:24 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232929, encodeId=d7c4232929d9, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Aug 12 19:52:35 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-19 虈亣靌

    讲解的非常好,值得学习

    0

  5. 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createdTime=Sun Aug 13 08:31:24 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232929, encodeId=d7c4232929d9, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Aug 12 19:52:35 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-15 ylzr123

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

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createdName=ms6897892027066920, createdTime=Sun Aug 13 23:37:00 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233168, encodeId=17fc233168fc, content=诱因只在标题?具体的呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Sun Aug 13 12:05:08 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233093, encodeId=caf723309376, content=讲解很好透彻, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce8c1961256, createdName=yongyuanaiping, createdTime=Sun Aug 13 08:31:24 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232929, encodeId=d7c4232929d9, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Aug 12 19:52:35 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-14 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

  7. 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createdTime=Sun Aug 13 08:31:24 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232929, encodeId=d7c4232929d9, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Aug 12 19:52:35 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-13 baihao215

    诱因只在标题?具体的呢?

    0

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createdName=ms6897892027066920, createdTime=Sun Aug 13 23:37:00 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233168, encodeId=17fc233168fc, content=诱因只在标题?具体的呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Sun Aug 13 12:05:08 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233093, encodeId=caf723309376, content=讲解很好透彻, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce8c1961256, createdName=yongyuanaiping, createdTime=Sun Aug 13 08:31:24 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232929, encodeId=d7c4232929d9, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Aug 12 19:52:35 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-13 yongyuanaiping

    讲解很好透彻

    0

  10. 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createdTime=Sun Aug 13 08:31:24 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232929, encodeId=d7c4232929d9, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Aug 12 19:52:35 CST 2017, time=2017-08-12, status=1, ipAttribution=)]
    2017-08-12 虈亣靌

    不错的,学习了!谢谢分享!

    0

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