Lancet:把根留住——阴茎移植。

2017-08-18 MedSci MedSci原创

因割礼而并发坏疽是南非年轻男性阴茎丢失的主要原因。根深蒂固的传统不容易废除。因为捐献部位的发病率会妨碍对阴茎植入物造成挤压的体力劳动和剧烈的性活动,利用游离血管组织皮瓣的阴茎移植物的传统重建手术不是很受欢迎。一个年轻人缺失阴茎的心理社会学效应是毁灭性的,阴茎移植或许可以带来巨大好处。

因割礼而并发坏疽是南非年轻男性阴茎丢失的主要原因。根深蒂固的传统不容易废除。因为捐献部位的发病率会妨碍对阴茎植入物造成挤压的体力劳动和剧烈的性活动,利用游离血管组织皮瓣的阴茎移植物的传统重建手术不是很受欢迎。一个年轻人缺失阴茎的心理社会学效应是毁灭性的,阴茎移植或许可以带来巨大好处。

研究人员先做了一个从尸体到尸体的阴茎移植作预实验。招募潜在的接受者,并筛查其生理和心理特征,包括阴茎残余的长度和心理适应性。遇到合适的供者,取其阴茎。手术处理受者阴茎残端并接上移植物。用抗胸腺免疫球蛋白、甲泼尼龙、他克莫司、霉酚酸酯和强的松行免疫抑制处理。推荐术后阴茎恢复一周后开始每天服用他达拉非(抑制阴茎勃起)5mg,持续3个月。分别于术前和随访过程中进行生活质量评分,并于移植后24个月检测阴茎勃起功能和尿流速。

手术持续9小时。术后8小时紧急处理动脉栓塞。术后6天,予以手术处理感染性血肿和近端坏死皮肤。1个月后出院,出院后一周反馈对性活动满意(尽管与建议相反)。术后3个月后开始规律的性行为。7个月时发生急性肾损伤,通过将他克莫司剂量减至14mg 2/日 后好转。术后8个月,发生皮肤暗丝孢霉菌皮肤感染,予以局部抗真菌药物治疗。术后生活质量评分显着提高(SF-36v2精神生活评分:术前25、术后6个月57、术后24个月46;精神健康评分:37、60、59)。24个月时,最大尿流速(16.3 mL/s)和IIEF评分均正常,提示小便和勃起功能均正常。

在该志愿者身上,阴茎移植恢复了其正常的生理功能,且在术后24个月内未见严重并发症。

原始出处:

Andre van der Merwe,et al.Penile allotransplantation for penis amputation following ritual circumcision: a case report with 24 months of follow-up.The Lancet.August 17,2017.http://dx.doi.org/10.1016/S0140-6736(17)31807-X

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    2018-04-15 howi
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    2017-08-26 海之蓝

    学习

    0

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    2017-08-20 qinqiyun

    腻害

    0

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    2017-08-20 dingxiaobo
  5. [GetPortalCommentsPageByObjectIdResponse(id=1829151, encodeId=257f1829151b4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Apr 15 15:36:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237356, encodeId=1cf023e356ba, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sat Aug 26 12:10:05 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235468, encodeId=955723546886, content=腻害, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=qinqiyun, createdTime=Sun Aug 20 19:49:03 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293884, encodeId=27f81293884a7, content=<a href='/topic/show?id=bdf29e54396' target=_blank style='color:#2F92EE;'>#阴茎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97543, encryptionId=bdf29e54396, topicName=阴茎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sun Aug 20 09:36:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537568, encodeId=9305153e56888, content=<a href='/topic/show?id=cbff9e5618a' target=_blank style='color:#2F92EE;'>#阴茎移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97561, encryptionId=cbff9e5618a, topicName=阴茎移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23e212872636, createdName=juliusluan82, createdTime=Sun Aug 20 09:36:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235030, encodeId=da70235030b8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Aug 19 09:25:36 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235007, encodeId=c18323500edf, content=超厉害的说, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Aug 19 08:51:10 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1829151, encodeId=257f1829151b4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Apr 15 15:36:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237356, encodeId=1cf023e356ba, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sat Aug 26 12:10:05 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235468, encodeId=955723546886, content=腻害, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=qinqiyun, createdTime=Sun Aug 20 19:49:03 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293884, encodeId=27f81293884a7, content=<a href='/topic/show?id=bdf29e54396' target=_blank style='color:#2F92EE;'>#阴茎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97543, encryptionId=bdf29e54396, topicName=阴茎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sun Aug 20 09:36:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537568, encodeId=9305153e56888, content=<a href='/topic/show?id=cbff9e5618a' target=_blank style='color:#2F92EE;'>#阴茎移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97561, encryptionId=cbff9e5618a, topicName=阴茎移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23e212872636, createdName=juliusluan82, createdTime=Sun Aug 20 09:36:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235030, encodeId=da70235030b8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Aug 19 09:25:36 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235007, encodeId=c18323500edf, content=超厉害的说, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Aug 19 08:51:10 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 130****4638

    学习了谢谢分享

    0

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    2017-08-19 戒馋,懒,贪

    超厉害的说

    0