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BMJ：新辅助化疗可提高晚期上皮性卵巢癌3年生存期

2018-01-05 zhangfan MedSci原创

上皮性卵巢癌新辅助化疗生存期
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研究认为对于晚期上皮性卵巢癌患者，接受新辅助化疗可使诊断后三年内死亡率大幅下降

近日研究人员评估了新辅助化疗(NACT)对晚期上皮性卵巢癌全死因死亡率的影响

2011-12年间，6034名3c-4期上皮性卵巢癌患者参与研究。研究的主要终点是3年的全因死亡率，采用Kaplan-Meier曲线以及比例风险模型考察组间死亡率的差异。

1156名患者接受新辅助化疗，4878人进行对照。研究发现，接受治疗的患者2012年间的死亡率较2011年降低（HR 0.81 95%CI 0.71-0.94），对照组无显著差异(1.02， 0.93-1.12)。与对照组相比，患者术后90天的死亡风险 (7.0%-4.0% vs 5.0% -4.3%， P=0.01)以及未进行放化疗治疗的患者比例(20.0%-17.4% vs 19.0-19.5%， P=0.04)降低。横断面分析显示接受NACT治疗地区患者死亡率较低(p=0.001)。

研究认为对于晚期上皮性卵巢癌患者，接受新辅助化疗可使诊断后三年内死亡率大幅下降。

原始出处：


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    2018-09-01 charl1234576

    #新辅助#

    0

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    2018-04-26 gaoxiaoe

    #BMJ#

    0

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    2018-12-04 ms1756883563247400

    #皮性卵巢癌#

    0

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encodeId=64e72e5713f0, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Jan 05 11:39:29 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275712, encodeId=c5ff2e57126b, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Jan 05 11:39:16 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275711, encodeId=73582e57112f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Jan 05 11:39:11 CST 2018, time=2018-01-05, status=1, ipAttribution=)]
    2018-07-06 hywen7334

    #上皮性卵巢癌#

    0

  5. 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objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b10c1938054, createdName=1e0e5697m83(暂无匿称), createdTime=Sat Jan 06 17:12:35 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275714, encodeId=16452e5714d0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Fri Jan 05 11:48:26 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275713, encodeId=64e72e5713f0, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Jan 05 11:39:29 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275712, encodeId=c5ff2e57126b, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Jan 05 11:39:16 CST 2018, time=2018-01-05, status=1, ipAttribution=), 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    2018-01-07 仁者大医

    #生存期#

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b10c1938054, createdName=1e0e5697m83(暂无匿称), createdTime=Sat Jan 06 17:12:35 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275714, encodeId=16452e5714d0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Fri Jan 05 11:48:26 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275713, encodeId=64e72e5713f0, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Jan 05 11:39:29 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275712, encodeId=c5ff2e57126b, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Jan 05 11:39:16 CST 2018, time=2018-01-05, status=1, ipAttribution=), 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    2018-01-06 1e0e5697m83(暂无匿称)

    henhao

    0

  7. 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    2018-01-05 llaq

    学习

    0

  8. 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    2018-01-05 xiaotao112411

    学习学习学习

    0

  9. 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    2018-01-05 xiaotao112411

    学习学习学习

    0

  10. 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    2018-01-05 xiaotao112411

    学习学习学习

    0

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