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J Immunol：胶原蛋白VI含有多种有效活性的宿主防御肽，可有效对抗感染

2018-06-26 MedSci MedSci原创

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胶原蛋白VI是一种无处不在的细胞外基质成分，在大多数结缔组织中形成广泛的微纤维网状结构。在这项研究中，研究人员首次描述了胶原蛋白VI血管性血友病因子A型结构域在人体皮肤感染中表现出对革兰氏阳性和革兰氏阴性菌的广谱抗菌活性。 VWA结构域的计算机序列和结构分析显示，胶原蛋白VI含有阳离子和两亲性肽序列基序，这可能解释了胶原蛋白VI的抗菌特性。体外和体内研究显示，这些肽通过膜破裂对金黄色葡萄球菌、大肠

胶原蛋白VI是一种无处不在的细胞外基质成分，在大多数结缔组织中形成广泛的微纤维网状结构。在这项研究中，研究人员首次描述了胶原蛋白VI血管性血友病因子A型结构域在人体皮肤感染中表现出对革兰氏阳性和革兰氏阴性菌的广谱抗菌活性。

VWA结构域的计算机序列和结构分析显示，胶原蛋白VI含有阳离子和两亲性肽序列基序，这可能解释了胶原蛋白VI的抗菌特性。体外和体内研究显示，这些肽通过膜破裂对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌显示出显著的抗菌活性。

综上所述，该研究结果揭示了胶原蛋白VI衍生肽在先天宿主防御中的作用，并为开发基于肽的抗菌疗法提供了模板。

原始出处：

Abdillahi SM, Maaß T, et al., Collagen VI Contains Multiple Host Defense Peptides with Potent In Vivo Activity. J Immunol. 2018 Jun 20. pii: ji1700602. doi: 10.4049/jimmunol.1700602.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=329620, encodeId=bf1932962064, content=学习了.好文章., beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Jul 06 00:15:17 CST 2018, time=2018-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329353, encodeId=d9db32935385, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jul 05 00:16:14 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329262, encodeId=43aa3292624b, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Jul 04 16:40:26 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404711, encodeId=ad7c1404e116e, content=<a href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46499, encryptionId=1a4f4649925, topicName=宿主)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/08904ED76550A0090DB220A7FB81D755/100, createdBy=78512492586, createdName=wincls, createdTime=Thu Jun 28 05:02:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485705, encodeId=a53c1485e0517, content=<a href='/topic/show?id=8f0c840392a' target=_blank style='color:#2F92EE;'>#胶原蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84039, encryptionId=8f0c840392a, topicName=胶原蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc8038511, createdName=12498e5fm14(暂无昵称), createdTime=Thu Jun 28 05:02:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327349, encodeId=2fb432e3499d, content=应该属于固有免疫的一部分吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Wed Jun 27 07:20:34 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-07-06 1e0f8808m18(暂无匿称)

    学习了.好文章.

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=329620, encodeId=bf1932962064, content=学习了.好文章., beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Jul 06 00:15:17 CST 2018, time=2018-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329353, encodeId=d9db32935385, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jul 05 00:16:14 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329262, encodeId=43aa3292624b, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Jul 04 16:40:26 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404711, encodeId=ad7c1404e116e, content=<a href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46499, encryptionId=1a4f4649925, topicName=宿主)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/08904ED76550A0090DB220A7FB81D755/100, createdBy=78512492586, createdName=wincls, createdTime=Thu Jun 28 05:02:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485705, encodeId=a53c1485e0517, content=<a href='/topic/show?id=8f0c840392a' target=_blank style='color:#2F92EE;'>#胶原蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84039, encryptionId=8f0c840392a, topicName=胶原蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc8038511, createdName=12498e5fm14(暂无昵称), createdTime=Thu Jun 28 05:02:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327349, encodeId=2fb432e3499d, content=应该属于固有免疫的一部分吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Wed Jun 27 07:20:34 CST 2018, time=2018-06-27, status=1, ipAttribution=)]
    2018-07-05 1e0f8808m18(暂无匿称)

    学习了.谢谢分享!

    0

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    2018-07-04 1e0f8808m18(暂无匿称)

    学习了.谢谢分享!

    0

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    2018-06-28 wincls

    #宿主#

    0

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    2018-06-28 12498e5fm14(暂无昵称)

    #胶原蛋白#

    0

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    2018-06-27 吴教授

    应该属于固有免疫的一部分吧

    0