Dig Liver Dis: 肠粘膜相关微生物群比粪便微生物群更好地揭示了炎症性肠病的模式差异

2019-05-21 不详 MedSci原创

越来越多的证据表明肠道微生物群在炎症性肠病(IBD)的病理生理学中发挥着潜在作用。本研究的目的是评估IBD患者与健康对照(CTRL)相比的粘膜(MM)和粪便微生物群(FM)组成成分差异。

背景
越来越多的证据表明肠道微生物群在炎症性肠病(IBD)的病理生理学中发挥着潜在作用。本研究的目的是评估IBD患者与健康对照(CTRL)相比的粘膜(MM)和粪便微生物群(FM)组成成分差异。

方法
研究人员从14名IBD患者和11名CTRL组收集粪便和粘膜样品。在454-Junior基因组测序仪上扩增16S rRNA基因座的V1-V3区域,并与针对Greengenes数据库匹配的OTU进行比对。

结果
结果显示无论疾病病变部位和是否处于活动,在IBD的MM患者的变形菌(尤其是肠杆菌科的统计显着增加)和厚壁菌门(特别是罗斯氏和Faecalibacterium prausnitzii菌明显减少)和放线菌有明显差异。

结论
IBD患者的FM特征与CTRL比较相似,表明粘附于肠粘膜的微生物群才是区分IBD患者与健康对照的有效生物标志物。

原始出处:

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    2020-02-25 guoyibin
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    2019-05-23 Homburg
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已经有文献报道,克罗恩病或溃疡性结肠炎患者易出现肝胆和胰腺疾病并发症。因此,本项研究旨在探究炎症性肠病中肝胆和胰腺表现的流行程度及其与疾病本身和所用药物的关系。