BMJ Open:独立性言语障碍的卒中患者溶栓治疗的比例较低

2015-11-28 phylis 译 MedSci原创

目标:描述静脉溶栓治疗(IVT)患者中独立的语言障碍的频率及预后。设计:SITS国际卒中溶栓注册的患者(SITS-ISTR)参与者:2002年12月到2012年12月进行IVT治疗的脑卒中患者(n = 58293)。设置:一个多民族、前瞻性、观察性监测的登记记录。主要观察指标:独立的语言障碍和mRS方法:研究者通过基线国立卫生院卒中量表(NIHSS)识别独立的语言障碍的患者。研究者统计患者基线资料

目标:描述静脉溶栓治疗(IVT)患者中独立的语言障碍的频率及预后。

设计:SITS国际卒中溶栓注册的患者(SITS-ISTR)

参与者:2002年12月到2012年12月进行IVT治疗的脑卒中患者(n = 58293)。

设置:一个多民族、前瞻性、观察性监测的登记记录。

主要观察指标:独立的语言障碍和mRS

方法:研究者通过基线国立卫生院卒中量表(NIHSS)识别独立的语言障碍的患者。研究者统计患者基线资料及人口学数据,并报告患者特征,影像学数据集7天内NHISS分数及3个月mRS。研究者报道了从SITS-ISTR队列的相关数据。

结果:研究者发现进行IVT治疗的患者基线存在言语障碍者占1.14%(663/58 293)。与SITS-ISTR其他患者相比,言语障碍的患者治疗开始时间较长,入院影像学扫描可视梗塞的比例较低,因大血管引起的卒中较少见。2.3%的患者发生症状性脑出血,5.5%的患者存在致死性预后。7天,50%的言语障碍的患者完全恢复。3个月,86.3%的患者功能预后良好(mRS 0-2),71.7%的患者预后良好(mRS0-1),45.5%患者mRS为0。

结论:卒中后静脉溶栓治疗的患者中原本有言语障碍者的比例较低,且进行静脉溶栓治疗后,一半的原本有语言障碍的卒中患者在7天内完全恢复。

原文出处:

Lundström E, Zini A, Wahlgren N, Ahmed N. How common is isolated dysphasia among patients with stroke treated with intravenous thrombolysis, and what is their outcome? Results from the SITS-ISTR.  BMJ Open. 2015,Nov 25


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    2016-08-29 智智灵药
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    2016-03-20 仁者大医
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    2015-11-30 lqvr