N Engl J Med:与面粉相关的产志贺毒素大肠杆菌感染

2017-12-26 吴星 环球医学

2017年发表于《N Engl J Med》上的一项研究,考察了与面粉相关的产志贺毒素大肠杆菌(STEC)感染。

2017年发表于《N Engl J Med》上的一项研究,考察了与面粉相关的产志贺毒素大肠杆菌(STEC)感染

背景:2016年,多个司法管辖区团队调查了大型国内生产企业的污染面粉相关的STEC血清型O121和O26的爆发情况。

方法:病例来自2015年12月21日~2016年9月5日发病的暴发株感染疾病。为了识别与爆发相关的暴露,爆发病例与非STEC肠道疾病病例进行了比较,并根据年龄、性别和居住地进行了配对。疑似与爆发相关的产品进行了STEC检测,并寻找了污染的共同点。对临床和食物样本分离株进行了全基因组测序。

结果:总共从24地鉴别出56个病例。22个配对集的单变量精确条件逻辑回归模型表明,感染与使用一种牌子的面粉(OR,21.04;95% CI,4.69~94.37)和食用未熟的自制面团或面糊(OR,36.02;95% CI,4.63~280.17)显着相关。实验室检测从面粉样本中分离出爆发菌株,全基因组测序显示,临床和食物样本的分离株在遗传上彼此密切相关。追溯调查鉴别出常见的面粉生产设备。

结论:该调查显示,原料面粉为STEC感染的爆发源。虽然原料面粉是一种低水分食品,但是能成为食源性致病菌的载体。

原始出处:

Crowe SJ, Bottichio L, Shade LN,et al. Shiga Toxin-Producing E. coli Infections Associated with Flour. N Engl J Med. 2017 Nov 23;377(21):2036-2043. doi: 10.1056/NEJMoa1615910.

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    2018-03-22 haouestc
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    2018-12-06 spoonycyy
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    2017-12-30 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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