J Clin Gastroenterol:揭开法国肝硬化患者白蛋白的应用情况

2017-10-23 吴星 环球医学

2017年8月,发表在《J Clin Gastroenterol》的一项研究调查了法国肝硬化患者中白蛋白的应用情况。

2017年8月,发表在《J Clin Gastroenterol》的一项研究调查了法国肝硬化患者中白蛋白的应用情况。

简介:人白蛋白越来越多地用于肝硬化管理。在治疗穿刺(TP)、自发性腹膜炎(SBP)和1型肝肾综合征(HRS)中的推荐已经发表。本调查的目的是评价法国肝病胃肠病学家白蛋白的处方行为。

方法:联系所有的肝病胃肠病学家。调查问卷评价了(1)白蛋白应用的正确的指征,(2)白蛋白处方用于未经证实的临床情况。

结果:分析451位(50.1%)医师的回复。医师平均年龄为40岁(范围,24至67岁),从业于一所大学附属医院(47.7%)或初级医院(45.8%),56.7%的医师为高级医师。超过99.6%的医师获得TP相关补偿。87.8%的医师曾使用白蛋白,84.6%的医师使用固定剂量的白蛋白。对于SBP,94%的医师同时使用白蛋白和抗菌药。56.2%的医师遵循推荐方案:高级别的大学附属医院的医师比高级别的初级医院的医师更经常地遵循指南等文件的推荐(P=0.015)。约有66.5%的医师在诊断HRS的患者中使用白蛋白输注:高级别的大学附属医院的医师更频繁地使用(P=0.0006)。84%的医师同时使用白蛋白和血管加压素进行治疗;剂量和疗程变化较大。约有23.5%的医师使用白蛋白治疗细菌感染,47.9%的医师治疗低钠血症,43.9%的医师治疗重度低白蛋白血症,65.9%的医师治疗胸腔积液。

结论:在这项法国调查中,白蛋白处方仅与TP的推荐保持一致。仅有56%的医师遵循SBP方案。对于了解甚少的使用白蛋白治疗HRS不适合推荐,表明其更应该得到普及。

原始出处

Garioud A, Cadranel JF, Pauwels A, et al. Albumin Use in Patients With Cirrhosis in France: Results of the "ALBU-LIVE" Survey: A Case for Better EASL Guidelines Diffusion and/or Revision. J Clin Gastroenterol. 2017 Aug 4. doi: 10.1097/MCG.0000000000000735.

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    2018-07-18 许安
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    2017-10-25 珙桐
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    2017-10-25 neurowu
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    2017-10-23 天涯183

    非常好的文章.学习了

    0

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