Neurology:动脉瘤蛛网膜下腔出血死亡原因随时间变化

2015-11-26 phylis 译 MedSci原创

目的:比较同一机构,2个时期动脉瘤蛛网膜下腔出血(aSAH)住院死亡的原因。方法:从一个前瞻性收集机构数据库中,筛选出1999-2002年和2009-2012年间aSAH小于三天的844名患者。研究者评估90天内病例的死亡率,入院死亡原因,应用Poisson回归分析计算个人死亡原因校正RR值及相应95%CI,第一时间点为参照组。结果: 1999-2002年到2009-2012年90天死亡率从150

目的:比较同一机构,2个时期动脉瘤蛛网膜下腔出血(aSAH)住院死亡的原因。

方法:从一个前瞻性收集机构的数据库中,筛选出1999-2002年和2009-2012年间aSAH小于三天的844名患者。研究者评估90天内病例的死亡率、入院死亡原因、应用Poisson回归分析计算个人死亡原因校正RR值及相应95%CI,第一时间点为参照组。

结果:1999-2002年到2009-2012年90天死亡率从150/381(39%)下降到140 / 463(30%)
(aRR 0.74 , 95% CI 0.62-0.88 )。 与1999-2002年相比,2009-2012年因最初出血而死亡的aRR为1.06(95% CI 0.72-1.56),再出血死亡的aRR为0.47(95% CI 0.31-0.71)和迟发性脑缺血死亡的aRR值为0.91(95% CI 0.50-1.65)。随着时间的推移,入院再出血的患者比例从90/ 381(24%)下降到78 / 463(17%)(aRR 0.68 , 95% CI: 0.52-0.90),再出血时间的中位数从5天(IQR 1-10)降至0天(IQR 0-1),动脉瘤治疗时间的中位数从4天(IQR 2-13)降至1天(IQR 1-2)。

结论:入院死亡减少的一个重要因素是因再出血死亡的减少,这可能因为动脉瘤得到早期的治疗的原因。研究结果强调了早期阻断动脉瘤的必要性,及通过减少再出血的发生等其他措施对改善预后的必要性。

原文出处

Vergouwen MD, Jong-T,jien-Fa AV, Algra A, Rinkel GJ. Time trends in causes of death after aneurysmal subarachnoid hemorrhage: A hospital-based study. Neurology. 2015 Nov 20.


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