Stroke: n-3多不饱和脂肪酸可以降低缺血性中风的风险

2019-02-17 不详 MedSci原创

目前有理论认为饮食中的海洋n-3多不饱和脂肪酸(PUFA),特别是二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)的长期摄入与和缺血性中风风险降低有关。因此,本项研究旨在探究是否存在这样的关系。

背景和目的
目前有理论认为饮食中的海洋n-3多不饱和脂肪酸(PUFA),特别是二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)的长期摄入与和缺血性中风风险降低有关。因此,本项研究旨在探究是否存在这样的关系。

方法
研究人员纳入了57053名年龄在50至65岁的参与者。所有参与者均填写食物频率问卷,并在基线时进行脂肪组织活检。随访期间缺血性卒中的信息来自丹麦国家患者登记处。其中3203名受试者的病例和随机样本通过气相色谱法测定其脂肪组织的脂肪组成。

结果
本项研究平均随访时间为13.5年,1879名参与者发生了缺血性中风,EPA的脂肪组织含量与缺血性卒中呈负相关关系([HR],0.74; 95%CI,0.62-0.88)。此外,大动脉粥样硬化的发生率与海洋n-3 PUFA摄入量(HR,0.69; 95%CI,0.50-0.95),EPA(HR,0.66; 95%CI,0.48-0.91)和DHA (HR,0.72; 95%CI,0.53-0.99)和更高的EPA脂肪组织含量(HR,0.52; 95%CI,0.36-0.76)均有关系。总海洋n-3 PUFA(HR,2.50; 95%CI,1.38-4.53)和DHA(HR,2.12; 95%CI,1.21-3.69)以及脂肪含量较高时,心源性栓塞发生率较高。脂肪组织中的EPA含量与小血管闭塞呈负相关(HR,0.69; 95%CI,0.55-0.88)。

结论
除了心源性栓塞外,EPA与大多数类型缺血性卒中的风险较低相关。

原始出处:

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    2019-02-19 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

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