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J Dent Res：氧化锆表面固定I型胶原蛋白可更好的增强骨整合

2019-07-25 不详 网络

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氧化锆（ZrO2）牙种植体提供良好的生物相容性，具有良好的耐腐蚀性，并且具有与天然牙齿类似的颜色。不幸的是，ZrO2是一种生物惰性材料，因此难以实现骨整合。在这项研究中，我们试图通过使用喷砂和碱处理生产含有羟基的粗糙ZrO2表面（指定为ZSA）来增强骨整合。使用天然交联剂原花青素将I型胶原固定在ZSA表面上。结果进一步表明，ZSA-P / C中产生的表面比ZSA-C中产生的表面具有更多和更稳定的I

氧化锆（ZrO2）牙种植体提供良好的生物相容性，具有良好的耐腐蚀性，并且具有与天然牙齿类似的颜色。不幸的是，ZrO2是一种生物惰性材料，因此难以实现骨整合。在这项研究中，我们试图通过使用喷砂和碱处理生产含有羟基的粗糙ZrO2表面（指定为ZSA）来增强骨整合。

使用天然交联剂原花青素将I型胶原固定在ZSA表面上。结果进一步表明，ZSA-P / C中产生的表面比ZSA-C中产生的表面具有更多和更稳定的I型胶原。ZSA-P/C在人骨髓间充质干细胞的粘附，增殖和矿化方面也表现出优异的细胞反应。ZSA-P / C中增强的细胞反应是通过粘着斑激酶，AKT（磷酸肌醇3-激酶途径）和p38（促分裂原活化蛋白激酶途径）的延长激活而诱导的。

总之，本研究介绍的在粗糙的ZrO2表面上固定I型胶原蛋白的简单而新颖的方法可能有益于牙种植体应用。

原始出处：

Hsu CM, Sun YS, et al., Enhanced Cell Response to Zirconia Surface Immobilized with Type I Collagen. J Dent Res. 2019 May;98(5):556-563. doi: 10.1177/0022034519828702. Epub 2019 Feb 20.

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    2019-07-27 medsci248

    #氧化锆#

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    2019-07-27 12498e5fm14(暂无昵称)

    #胶原蛋白#

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    2019-07-27 bnurmamat

    #骨整合#

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    2019-07-25 一个字-牛

    学习了谢谢分享

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    2019-07-25 一个字-牛

    学习了谢谢分享

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