CID:从1994年到2018年美国带状疱疹和疱疹后神经痛发病率的变化

2021-09-14 从医路漫漫 MedSci原创

近几十年来,带状疱疹(HZ)的发病率呈上升趋势。虽然已经有两种HZ疫苗,但自从HZ和疱疹后神经痛(PHN)发生以来,很少有关于发病率的研究。

目的:近几十年来,带状疱疹(HZ)的发病率呈上升趋势。虽然已经有两种HZ疫苗,但自从HZ和疱疹后神经痛(PHN)发生以来,很少有关于发病率的研究。这项研究调查了美国1994-2018年赫兹和PHN的发病率,以确定自引入带状疱疹疫苗以来,它们是否继续增加。

方法:使用OptumLabs®数据仓库的非识别纵向行政索赔数据库,评估连续登记在数据库中≥365天且无HZ或PHN既往史的个人的发病率。非标准化和标准化发病率按年份、10岁年龄组、性别和种族/民族进行计算。

结果:61066例HZ患者(中位年龄,56.3岁[IQR: 43.0, 68.7]岁;59.8%的女性;白人占70.6%)。1994-2018年,HZ发病率从每10万人年286.0例(95% CI: 259.1, 312.8)上升至579.6例(95% CI: 554.2, 605.0),年增长率3.1% (95% CI: 2.5, 3.6)。自2007年以来,≤20岁和≥60岁人群的年HZ发病率有所下降。PHN的总发病率为每10万人年57.5例(95% CI: 56.0, 59.0)。2007 - 2018年HZ患者发生PHN的比例高于1994 - 2006年。

图1 1994 - 2018年按年龄分列的带状疱疹发病率

图2 1994年至2006年按性别分列的带状疱疹发病率的年变化与2007年至2018年的年变化

图3 1994年至2006年各种族带状疱疹发病率的年变化与2007年至2018年

图4 1994至2006年按年龄划分的带状疱疹患者疱疹后神经痛的比例与2007至2018年的比例

结论:在目前不推荐注射HZ疫苗的年龄组中,带状疱疹发病率持续上升,有必要对目前的疫苗推荐进行重新审查。

原文出处

Thompson RR,  Kong CL,  Porco TC,et al,Herpes Zoster and Post-Herpetic Neuralgia: Changing Incidence Rates from 1994 to 2018 in the United States.Clin Infect Dis 2020 Aug 23

 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1823749, encodeId=06451823e49ce, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Jul 14 01:55:59 CST 2022, time=2022-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991632, encodeId=00071991632d3, content=<a href='/topic/show?id=f88a4e047f' target=_blank style='color:#2F92EE;'>#CID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4704, encryptionId=f88a4e047f, topicName=CID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Thu Apr 28 07:55:59 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1210068, encodeId=74fb121006863, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c995401287, createdName=ms4000000579625590, createdTime=Sun Apr 10 17:04:15 CST 2022, time=2022-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540841, encodeId=f9ad154084155, content=<a href='/topic/show?id=ac8de440615' target=_blank style='color:#2F92EE;'>#神经痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74406, encryptionId=ac8de440615, topicName=神经痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0d8213287489, createdName=贵阳, createdTime=Thu Sep 16 01:55:59 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580470, encodeId=3f9c15804e0db, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Thu Sep 16 01:55:59 CST 2021, time=2021-09-16, status=1, ipAttribution=)]
    2022-04-28 xlxchina
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    2022-04-10 ms4000000579625590

    学习一下

    0

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    2021-09-16 贵阳
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