Molecular Metabolism:减少睡眠会改变与损害人体代谢健康相关的肠道菌群的数量

2016-10-26 MedSci MedSci原创

来自乌普萨拉大学的一项新的研究结果表明减少睡眠会改变与损害人体代谢健康相关的肠道菌群的数量,该研究结果已发表于Molecular Metabolism。 肠道菌群的组成及多样性的变化与人体的多个疾病有关,如肥胖和2型糖尿病。而这些疾病也与慢性失眠有关。然而,目前尚不清楚慢性失眠是否会改变人类的肠道微生物。 研究共纳入了9名正常体重的男性,探究与正常睡眠相比(约8个小时的睡眠),限制睡眠

来自乌普萨拉大学的一项新的研究结果表明减少睡眠会改变与损害人体代谢健康相关的肠道菌群的数量,该研究结果已发表于Molecular Metabolism。

肠道菌群的组成及多样性的变化与人体的多个疾病有关,如肥胖和2型糖尿病。而这些疾病也与慢性失眠有关。然而,目前尚不清楚慢性失眠是否会改变人类的肠道微生物。

研究共纳入了9名正常体重的男性,探究与正常睡眠相比(约8个小时的睡眠),限制睡眠至每晚四小时,连续两天,是否会改变人类的肠道菌群。

结果,研究并未能表明肠道菌群的多样性会因睡眠的限制而改变。这或与研究时间较短和样本量较小有关。但是在细菌群体更具体的分析中,研究人员确实发现了菌群的变化,如肥胖者与正常体重者相比,正如其他研究所示一样,如硬壁菌门到拟杆菌门的变化。需要更大样本量的研究更长时间的探究临床睡眠干预如何改变肠道微生物介导不良的健康结局,如体重增加和胰岛素抵抗。

此外,研究人员还发现,20%以上的参与者慢性失眠后对胰岛素不太敏感。而这种胰岛素敏感性降低与参与者失眠后肠道菌群的改变无关。这表明,微生物的改变,至少在短期内,不大可能会降低人类胰岛素敏感性。

最后,研究人员总结道,肠道菌群非常丰富,但是其功能远未完全了解。希望未来的研究能够确定肠道菌群的组成和功能如何在个人层面上影响机体代谢、认知及失眠。

原始出处:

Sleep loss tied to changes of the gut microbiota in humans. Science Daily, October 25, 2016.

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    2017-01-24 一闲
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    2017-02-14 guojianrong
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    2016-10-30 1e10c84am36(暂无匿称)

    不错,值得拜读

    0

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  5. 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  6. 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GetPortalCommentsPageByObjectIdResponse(id=151412, encodeId=b0f4151412ec, content=哎,我得调节自己的生物钟了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14251719934, createdName=卟离@雨相b81b8f28, createdTime=Thu Oct 27 02:11:33 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-10-28 闆锋旦
  8. 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    2016-10-27 flysky120

    谢谢,学习一下

    0

  9. 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    2016-10-27 童小孩

    继续学习继续关注

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=151412, encodeId=b0f4151412ec, content=哎,我得调节自己的生物钟了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14251719934, createdName=卟离@雨相b81b8f28, createdTime=Thu Oct 27 02:11:33 CST 2016, time=2016-10-27, status=1, ipAttribution=)]
    2016-10-27 卟离@雨相b81b8f28

    哎,我得调节自己的生物钟了

    0

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