Thyroid:缺铁是妊娠期甲状腺功能障碍的危险因素

2021-09-26 MedSci原创 MedSci原创

缺铁,而且轻度缺碘,是孕妇血清FT4和T4的决定因素。除了预防妊娠期间的贫血外,纠正缺铁可能有助于维持最佳的甲状腺功能。

缺铁会损伤依赖血红素的甲状腺过氧化物酶的活性,从而影响甲状腺激素的合成。目前,缺铁的患病率有所升高,尤其在孕妇中。

近日,甲状腺疾病领域权威杂志Thyroid上发表了一篇研究文章,这项研究旨在调查全国代表性的轻度碘缺乏孕妇样本中铁状态对甲状腺功能的影响。

研究人群包括比利时妊娠前三个月和第三个月的孕妇样本(n=1241)。根据多阶段与规模成比例的分层和整群抽样设计选择女性。收集受试者尿液和血液样本,并与研究护士面对面完成问卷。研究人员测量了受试者的FT4、总T4、FT3、TSH、甲状腺球蛋白(Tg)、甲状腺过氧化物酶抗体、甲状腺球蛋白抗体、血红蛋白、血清铁蛋白(SF)、可溶性转铁蛋白受体、尿碘浓度(UIC)的浓度和体内铁储备(BIS)计算。

妊娠早期和晚期的中位UIC分别为117和132µg/L(p<0.05)。SF<15µg/L在妊娠早期的频率为6.2%,妊娠晚期为39.6%(p<0.05)。尿碘浓度是血清Tg浓度的重要预测因子(p<0.01),但不是甲状腺激素或TSH浓度的重要预测因子。BIS阴性和BIS阳性孕妇中孕晚期FT4低于第10个百分位的频率分别为24%和14%(P<0.05)。血清铁蛋白和BIS是妊娠早期FT4和T4的重要预测因子(p<0.05)。血红蛋白是两个妊娠期(p<0.01)和妊娠晚期T4(p=0.015)和FT4的重要预测因子。

由此可见,缺铁,而且轻度缺碘,是孕妇血清FT4和T4的决定因素。除了预防妊娠期间的贫血外,纠正缺铁可能有助于维持最佳的甲状腺功能。

原始出处:

Rodrigo Moreno-Reyes,et al.Iron deficiency is a risk factor for thyroid dysfunction during pregnancy: A population-based study in Belgium.Thyroid.2021.https://doi.org/10.1089/thy.2021.0286

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createdName=luckyshitiancai_42705684, createdTime=Tue Sep 28 13:11:31 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421392, encodeId=164a142139264, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Sep 28 13:11:31 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055407, encodeId=7658105540e5e, content=轻度缺碘,是孕妇血清FT4和T4的决定因素。除了预防妊娠期间的贫血外,纠正缺铁可能有助于维持最佳的甲状腺功能。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Sep 27 06:23:40 CST 2021, time=2021-09-27, status=1, ipAttribution=)]
    2021-09-27 随梦飞扬

    轻度缺碘,是孕妇血清FT4和T4的决定因素。除了预防妊娠期间的贫血外,纠正缺铁可能有助于维持最佳的甲状腺功能。

    0

  5. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Sep 27 06:23:40 CST 2021, time=2021-09-27, status=1, ipAttribution=)]
    2021-09-27 tanxingdoctor

    学习了

    0

  6. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Sep 27 06:23:40 CST 2021, time=2021-09-27, status=1, ipAttribution=)]
    2021-09-27 乙娆

    一个新的研究方向

    0

  7. 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createdAvatar=, createdBy=af852494007, createdName=12484abcm62(暂无昵称), createdTime=Mon Sep 27 08:29:30 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055232, encodeId=5d74105523244, content=已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Mon Sep 27 07:29:47 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055221, encodeId=fd4b10552219a, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Sep 27 06:23:40 CST 2021, time=2021-09-27, status=1, ipAttribution=)]
    2021-09-27 ms5000000010611182

    学到了学到了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1251295, encodeId=f7911251295e6, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Sep 28 13:11:31 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395186, encodeId=31fc139518655, content=<a href='/topic/show?id=c268e940840' target=_blank style='color:#2F92EE;'>#缺铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79408, encryptionId=c268e940840, topicName=缺铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eb32500176, createdName=luckyshitiancai_42705684, createdTime=Tue Sep 28 13:11:31 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421392, encodeId=164a142139264, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Sep 28 13:11:31 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055407, encodeId=7658105540e5e, content=轻度缺碘,是孕妇血清FT4和T4的决定因素。除了预防妊娠期间的贫血外,纠正缺铁可能有助于维持最佳的甲状腺功能。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cec72111766, createdName=乙娆, createdTime=Mon Sep 27 11:33:29 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055285, encodeId=ce0f105528522, content=学到了学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210927/30864063bc47443e96a303cd98f47034/bc8b2ed3d43942dcb1386f5f98e48588.jpg, createdBy=34f55545437, createdName=ms5000000010611182, createdTime=Mon Sep 27 10:30:29 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055238, encodeId=7596105523868, content=123456, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af852494007, createdName=12484abcm62(暂无昵称), createdTime=Mon Sep 27 08:29:30 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055232, encodeId=5d74105523244, content=已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Mon Sep 27 07:29:47 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055221, encodeId=fd4b10552219a, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Sep 27 06:23:40 CST 2021, time=2021-09-27, status=1, ipAttribution=)]
    2021-09-27 12484abcm62(暂无昵称)

    123456

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1251295, encodeId=f7911251295e6, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Sep 28 13:11:31 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395186, encodeId=31fc139518655, content=<a href='/topic/show?id=c268e940840' target=_blank style='color:#2F92EE;'>#缺铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79408, encryptionId=c268e940840, topicName=缺铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eb32500176, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cec72111766, createdName=乙娆, createdTime=Mon Sep 27 11:33:29 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055285, encodeId=ce0f105528522, content=学到了学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210927/30864063bc47443e96a303cd98f47034/bc8b2ed3d43942dcb1386f5f98e48588.jpg, createdBy=34f55545437, createdName=ms5000000010611182, createdTime=Mon Sep 27 10:30:29 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055238, encodeId=7596105523868, content=123456, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af852494007, createdName=12484abcm62(暂无昵称), createdTime=Mon Sep 27 08:29:30 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055232, encodeId=5d74105523244, content=已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Mon Sep 27 07:29:47 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055221, encodeId=fd4b10552219a, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Sep 27 06:23:40 CST 2021, time=2021-09-27, status=1, ipAttribution=)]
    2021-09-27 ms5000000518166734

    已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1251295, encodeId=f7911251295e6, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Sep 28 13:11:31 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395186, encodeId=31fc139518655, content=<a href='/topic/show?id=c268e940840' target=_blank style='color:#2F92EE;'>#缺铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79408, encryptionId=c268e940840, topicName=缺铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eb32500176, createdName=luckyshitiancai_42705684, createdTime=Tue Sep 28 13:11:31 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421392, encodeId=164a142139264, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Sep 28 13:11:31 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055407, encodeId=7658105540e5e, content=轻度缺碘,是孕妇血清FT4和T4的决定因素。除了预防妊娠期间的贫血外,纠正缺铁可能有助于维持最佳的甲状腺功能。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cec72111766, createdName=乙娆, createdTime=Mon Sep 27 11:33:29 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055285, encodeId=ce0f105528522, content=学到了学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210927/30864063bc47443e96a303cd98f47034/bc8b2ed3d43942dcb1386f5f98e48588.jpg, createdBy=34f55545437, createdName=ms5000000010611182, createdTime=Mon Sep 27 10:30:29 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055238, encodeId=7596105523868, content=123456, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=af852494007, createdName=12484abcm62(暂无昵称), createdTime=Mon Sep 27 08:29:30 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055232, encodeId=5d74105523244, content=已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Mon Sep 27 07:29:47 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055221, encodeId=fd4b10552219a, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Sep 27 06:23:40 CST 2021, time=2021-09-27, status=1, ipAttribution=)]
    2021-09-27 yangchou

    好文章,谢谢分享。

    0

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