Oncol Lett：靶向mir-381或可用于胃癌的治疗

2017-11-11 MedSci MedSci原创

微小RNA（miRs）表达的异常在人类癌症的发生发展过程中起着非常重要的作用。本研究中，研究人员重点探究了mir-381在胃癌（GC）组织中的表达及生物学功能。逆转录-定量聚合酶链反应分析结果显示，胃癌组织样本中mir-381的表达明显下调。此外，研究人员确定mir-381的表达水平较低与淋巴结转移和晚期肿瘤的淋巴结转移阶段相关（Ⅲ+Ⅳ）。上调mir-381可抑制GC SGC-7901细胞的侵袭迁

微小RNA（miRs）表达的异常在人类癌症的发生发展过程中起着非常重要的作用。本研究中，研究人员重点探究了mir-381在胃癌（GC）组织中的表达及生物学功能。

逆转录-定量聚合酶链反应分析结果显示，胃癌组织样本中mir-381的表达明显下调。此外，研究人员确定mir-381的表达水平较低与淋巴结转移和晚期肿瘤的淋巴结转移阶段相关（Ⅲ+Ⅳ）。上调mir-381可抑制GC SGC-7901细胞的侵袭迁移能力，机制上是通过SRY-Box 4 (SOX4)介导的上皮间质转化。最后，研究人员发现TUG1负调节mir-381 SGC-7901在细胞中的表达。

总之，目前的研究结果表明，通过对mir-381 lncrna-tug1下调可抑制胃癌细胞的转移。因此，靶向mir-381或是GC治疗的一种方法。

原始出处：

Zhang M, Huang S, Long D.MiR-381 inhibits migration and invasion in human gastric carcinoma through downregulatedting SOX4.Oncol Lett. 2017 Sep;14(3):3760-3766. doi: 10.3892/ol.2017.6637. Epub 2017 Jul 20.

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#插入话题

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2018-09-12 jiafufeng@yaho

#miR-381#

38 0
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2018-05-10 minlingfeng

#Oncol#

34 0
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2018-04-19 smallant2002

#miR#

39 0
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2017-11-23 虈亣靌

好好学习努力向上

54 0
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2017-11-17 虈亣靌

好消息.值得学习

61 0
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2017-11-12 虈亣靌

优质资源.共同学习

47 0
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2017-11-11 Y—xianghai

学习了新知识

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