Circulation:下肢动脉血栓患者需警惕是否已身患癌症!

2018-08-16 MedSci MedSci原创

静脉血栓是癌症的一种常见临床表现,但下肢动脉血栓与癌症是否存在相关性尚不明确。现研究人员对下肢动脉血栓患者的癌症风险及预后进行评估。研究人员根据丹麦国家医疗登记处获得首次确诊下肢动脉血栓的患者(1994-2013),随访至确诊罹患癌症、移民、死亡或截止2013年11月30日。计算标准化发病率,并构建一相匹配的无下肢动脉血栓的癌症患者作为比较队列,检验下肢动脉血栓形成对罹患癌症后的全因死亡率的影响。

静脉血栓是癌症的一种常见临床表现,但下肢动脉血栓与癌症是否存在相关性尚不明确。现研究人员对下肢动脉血栓患者的癌症风险及预后进行评估。

研究人员根据丹麦国家医疗登记处获得首次确诊下肢动脉血栓的患者(1994-2013),随访至确诊罹患癌症、移民、死亡或截止2013年11月30日。计算标准化发病率,并构建一相匹配的无下肢动脉血栓的癌症患者作为比较队列,检验下肢动脉血栓形成对罹患癌症后的全因死亡率的影响。

研究人员共筛选到6600位下肢动脉血栓患者,其中772位在随访过程中罹患癌症。随访6个月时的癌症风险为2.5%,随访20年时增高至17.9%。在随访的前6个月,癌症的标准化发病率为3.28(95% CI 2.79-3.82)。随访7-12个月和12个月后癌症的标准化发病率仍保持较高水平(1.42,95% CI 1.09-1.83和1.14,95% CI 1.05-1.24)。相关性在肺癌和其他吸烟相关癌症中最强。下肢动脉血栓还与罹患大肠癌、肺癌、膀胱癌以及乳腺癌后的全因死亡率增高相关,但与患前列腺癌后的死亡率无相关性。

下肢动脉血栓是隐匿性癌症(特别是肺癌)的一个标志,可作为常见癌症死亡率的一个不良预后因素。


原始出处:

Jens Sundboll,et al. Risk and Prognosis of Cancer After Lower Limb Arterial Thrombosis. Circulation. 2018;138:669-67

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    2018-10-07 秀红

    学习了

    0

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    2018-08-18 lq0307