the American Journal of Clinical Nutrition :低 omega-3 指数与吸烟一样是早逝的有力预测指标

2021-06-27 网络 网络

心血管疾病仍然是全球主要的死亡原因,可以通过改变不健康饮食、增加运动和戒烟草和酒精等行为因素来降低风险。

血管疾病仍然是全球主要的死亡原因,可以通过改变不健康饮食、增加运动和戒烟草和酒精等行为因素来降低风险。

基于饮食的生物标志物包括脂肪酸(FA),其中与降低心血管疾病风险和总死亡率(即任何原因导致的死亡)最明显相关的脂肪酸是 omega-3 脂肪酸、EPA 和 DHA,它们通常存在于鲑鱼和鲱鱼等鱼类中,以及 omega-3补充剂,如鱼和藻油。

上周发表在《美国临床营养学杂志》上的一篇新研究论文表明,低 omega-3 指数在预测早逝方面与吸烟一样有效。弗雷明汉心脏研究提供了对心血管疾病 (CVD) 风险因素的独特见解,并基于八项基线标准风险因素——年龄、性别、吸烟、高血压治疗、糖尿病状态、收缩压、总胆固醇 (TC) 和 HDL 胆固醇。研究员比较RBC FA  水平与心血管疾病(CVD) 标准危险因素的组合在预测全因死亡风险方面的作用。

研究发现基线 RBC EPA + DHA 含量 [omega-3指数(O3I)] 显着且与全因死亡风险呈负相关。与那些 omega-3 指数最低的人相比,omega-3 指数最高的人在后续死亡风险的可能性要低 33%。

omega-3 指数测量红细胞膜中 EPA 和 DHA 的含量,是 omega-3 状态的标志。最佳 omega-3 指数为 8% 或更高,中等 omega-3 指数为 4% 至 8%,低 omega-3 指数为 4% 及以下。大多数美国人的 omega-3 指数低于 4%,这使他们过早死亡的风险显着增加。

28 个FA 指标中的四个 [14:016:1n–722:0 和 omega-3 指数  出现在 ≥5 个发现模型中,如全因死亡率的重要预测因子。在年龄和性别调整模型中,具有 4 个 FA 指标的模型在预测全因死亡率方面至少与包含其余 6 个标准风险因素的模型一样好(C 统计量:0.778;95% CI:0.759、0.797 ;与 C 统计量相比:0.777;95% CI:0.753, 0.802)。与单独的 FA ( P  < 0.01) 或 Sm + D 模型相比,具有 4 个 FA 指标加上吸烟和糖尿病 (FA + Sm + D) 的模型具有更高的 C 统计量 (0.790; 95% CI: 0.770, 0.811) C 统计量:0.766;95% CI:0.739、0.794;P < 0.001)。

 根据这项研究中的研究人员的说法,任何基于 FA 的指标都具有与公认的标准风险因素相似的预测能力的发现是出乎意料的,这表明 RBC FAs——通过不完全理解的机制——以某种方式反映了体内将所有这些标准风险因素对身体的影响合并为一个衡量标准的环境。因此,这项研究中的研究人员表示,结合生活方式选择的生物标志物可能有助于识别有风险的个体,并有助于评估治疗方法、预防发病率和延迟死亡。

“有趣的是,在日本,平均 omega-3 指数大于 8%,预期寿命比美国长约五年,美国的平均 omega-3 指数约为 5 %。因此,在实践中,改变 omega-3 指数的饮食选择可能会延长寿命,”本研究的首席研究员、FCNS-SCN 的 Michael McBurney 博士说。“在最终的组合模型中,吸烟和 omega-3 指数似乎是最容易改变的风险因素。目前吸烟者(65 岁)预计会减少四年以上的寿命(与不吸烟相比)

“在预测总死亡率方面,四种红细胞脂肪酸浓度中携带的信息与血脂水平、血压、吸烟和糖尿病状态中携带的信息一样有用,”比尔哈里斯博士说,他也是一名本研究的作者。“这说明了 omega-3 指数作为风险因素的力量,应该被视为与其他既定风险因素一样重要,甚至可能更重要。”

参考文献:

Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort The American Journal of Clinical Nutrition, nqab195, https://doi.org/10.1093/ajcn/nqab195

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1661645, encodeId=947716616453f, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Fri Mar 25 12:44:24 CST 2022, time=2022-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977857, encodeId=99069e785704, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f0c5536654, createdName=陈嘉伟, createdTime=Tue Jun 29 10:23:30 CST 2021, time=2021-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407064, encodeId=3aff140e064e6, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Tue Jun 29 03:44:24 CST 2021, time=2021-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507761, encodeId=f66b150e76139, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Tue Jun 29 03:44:24 CST 2021, time=2021-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977345, encodeId=d5479e73458d, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e635479749, createdName=ms2000002016659512, createdTime=Sun Jun 27 16:04:48 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977279, encodeId=111c9e727914, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32515535103, createdName=小可爱萌萌, createdTime=Sun Jun 27 13:07:22 CST 2021, time=2021-06-27, status=1, ipAttribution=)]
    2021-06-29 陈嘉伟

    文章不错

    0

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    2021-06-29 zll0628
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    2021-06-27 ms2000002016659512

    很好

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1661645, encodeId=947716616453f, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Fri Mar 25 12:44:24 CST 2022, time=2022-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977857, encodeId=99069e785704, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f0c5536654, createdName=陈嘉伟, createdTime=Tue Jun 29 10:23:30 CST 2021, time=2021-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407064, encodeId=3aff140e064e6, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Tue Jun 29 03:44:24 CST 2021, time=2021-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507761, encodeId=f66b150e76139, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Tue Jun 29 03:44:24 CST 2021, time=2021-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977345, encodeId=d5479e73458d, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e635479749, createdName=ms2000002016659512, createdTime=Sun Jun 27 16:04:48 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977279, encodeId=111c9e727914, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32515535103, createdName=小可爱萌萌, createdTime=Sun Jun 27 13:07:22 CST 2021, time=2021-06-27, status=1, ipAttribution=)]
    2021-06-27 小可爱萌萌

    文章不错

    0