Gut:不同组织学溃疡性结肠炎评价标准一致性及准确性研究

2018-02-05 zhangfan MedSci原创

研究认为,Geboes评分、Nancyindex和Robartshist病理指数等溃疡性结肠炎组织评估方法对患者疾病分层具有较高的一致性,上皮中性粒细胞阳性是组织学活动的主要标志

目前,溃疡性结肠炎患者组织学缓解是公认的治疗终点。近日研究人员考察了三种组织学分类系统--Geboes评分(GS)、Nancyindex(Ni)和Robartshist病理指数(RHI) 与内镜结果和粪钙保护素 (FC)水平之间的关系。

研究采集了377名UC患者样本,进行GS, NI和RHI评估,评估结果与内镜得分以及FC水平进行比较。

研究发现,GS, NI 以及 RHI对于患者组织学缓解或疾病活动鉴别区别具有很好的一致性。RHI结果与NI接近--NI认定缓解的患者,RHI认定缓解率为100%,RHI认定疾病活动期的患者,NI也认定为疾病活动。组织学评估结果与内镜评估以及FC水平具有较高的一致性,表现出较好的敏感性及特异性。研究发现,较高的FC水平与上皮中性粒细胞阳性以及肠粘膜溃疡或糜烂有关。

研究认为,Geboes评分、Nancyindex和Robartshist病理指数等溃疡性结肠炎组织评估方法对患者疾病分层具有较高的一致性,上皮中性粒细胞阳性是组织学活动的主要标志。

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    2018-11-03 nymo
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    2018-11-25 zhanfl
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    2018-02-15 天涯183

    非常好的文章.学习了

    0

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    2018-02-14 jyzxjiangqin

    不同组织学溃疡性结肠炎.

    0

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    2018-02-07 huagfeg
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    2018-02-05 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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