Int Oral Max Surg:FMISO-PET评价低氧体积作为口腔鳞状细胞癌预后的因素之一

2018-04-08 MedSci MedSci原创

18F-氟米松硝苯胺正电子发射断层扫描(FMISO-PET)可检测肿瘤缺氧。很少有研究评估新的PET参数(包括缺氧量(HV),代谢肿瘤体积(MTV)和总病灶糖酵解(TLG))与手术治疗的口腔鳞状细胞癌(OSCC)患者的5年生存率之间的关系。

18F-氟米松硝苯胺正电子发射断层扫描(FMISO-PET)可检测肿瘤缺氧。很少有研究评估新的PET参数(包括缺氧量(HV),代谢肿瘤体积(MTV)和总病灶糖酵解(TLG))与手术治疗的口腔鳞状细胞癌(OSCC)患者的5年生存率之间的关系。

本研究评估了这些PET参数与OSCC患者5年生存率之间的关系。 23例OSCC患者(年龄42-84岁,男性15例,女性8例)在手术前接受FMISO-和18F-氟代-2-脱氧葡萄糖(FDG)-PET计算机断层扫描。他们都接受根治性手术且随访超过5年。测量FDG-PET最大标准摄取值(SUVmax),HV,MTV和TLG。采用受试者工作特征曲线分析评估PET参数预测无病生存(DFS)和局部区域复发(LR)的能力。在随访期间,23例患者中有5例(22%)死亡,6例(26%)患有LR。尽管FDG-PET SUVmax与DFS或LR无显着相关性,但HV与DFS和LR均显着相关。 TLG,而不是MTV,与DFS显着相关;然而,MTV和TLG与LR都无显着相关关系。总之,肿瘤HV可以预测OSCC患者的预后。

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    2018-08-02 小几洁
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    2018-12-19 feather89
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    2018-04-10 huagfeg