BMC Nephrol:中山大学孙逸仙医院学者称,三成腹主动脉瘤术后急性肾损伤,院内死亡率增加4倍

2017-06-06 许婧 中国循环杂志

中山大学孙逸仙医院学者发现,1/3的腹主动脉瘤患者在术后发生急性肾损伤,术前肌酐清除率降低、心血管疾病、动脉瘤破裂的患者在术后易发生急性肾损伤。

中山大学孙逸仙医院学者发现,1/3的腹主动脉瘤患者在术后发生急性肾损伤,术前肌酐清除率降低、心血管疾病、动脉瘤破裂的患者在术后易发生急性肾损伤。

本研究中,314例腹主动脉瘤修复术后患者中,急性肾损伤发生率为29.9%,发生急性肾损伤患者的院内死亡率是无肾损伤患者的4倍多(13.8% vs. 3.2%)。

腔内修复术患者的急性肾损伤发生率显着低于开放性动脉瘤修复术的患者(27.1% vs. 42.8%),而且主动脉瘤破裂患者的急性肾损伤发生率显着高于未破裂患者(48.1% vs 26.2%)。

开放性动脉瘤修复术和主动脉瘤破裂是修复术后急性肾损伤的独立预测因素。

亚组分析显示,腹主动脉瘤破裂患者采用腔内修复术可降低急性肾损伤发生率,而

采用开放性动脉瘤修复术,则术后急性肾损伤发生风险增加22倍。为了避免肾损伤的发生,这类患者要优选腔内修复术。

研究者指出,临床上严重低估了腹主动脉瘤患者术后急性肾损伤的发生,出院诊断急性肾损伤的发生率仅为2.5%。

研究者建议采用KDIGO 标准用于评估腹主动脉瘤患者术后AKI风险, 有助于AKI的早期识别和早期干预。

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    2017-06-06 flysky120

    为什么会肾损伤呢?

    0

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氧化应激在腹主动脉瘤的发生发展中起关键作用,而肾上腺髓质素2(IMD)是氧化应激的调节因子。近期发表于血管权威杂志ATVB上的一项报道研究研究肾上腺髓质素2是否通过抑制氧化应激减轻腹主动脉瘤。

Ann Surg:β阻断剂可以减少腹主动脉瘤术后死亡率

腹主动脉瘤(OAR)术后的死亡率为3.0%〜4.5%。但是,目前尚缺乏关于β受体阻滞剂(BB)对OAR术后死亡率的影响的相关研究。近期,一项发表在杂志Ann Surg上研究旨在评估围手术期使用BB对开腹修复OAR术后患者的住院死亡率的影响。此项研究是对2009年第3季度至2015年第一季度在Premier Healthcare数据库中进行OAR的患者的回顾性研究。Premier Healthcar

JAHA:男性生活方式和风险筛查检测腹主动脉瘤!

该前瞻性研究证实改变生活方式相关的因素与AAD和AAA疾病相关。

Lancet:男女有别——女性腹主动脉瘤患者预后差

女性患者适用腔内动脉瘤修复术的比例较男性低,保守治疗比例比男性高,而且女性患者动脉瘤修复术30天死亡率高于男性。对于女性腹主动脉瘤患者的治疗需要大幅度的改进。

盘点:近期腹主动脉瘤相关研究精华一览

腹主动脉瘤是指腹主动脉呈瘤样扩张,通常直径增大50%以上定义为动脉瘤。腹主动脉瘤好发于老年男性,男女之比为10:3,尤其是吸烟者,吸烟也显著增加动脉瘤破裂风险。绝大多数的腹主动脉瘤为肾动脉水平以下的病变。梅斯医学编辑为盘点了期腹主动脉瘤相关研究,与大家一起分享。【1】Br J Surg:腹主动脉瘤破裂率研究已有研究表明,腹主动脉瘤(AAAs)的发病率和破裂率均在下降。研究目的是,评估芬兰南部赫

新英格兰杂志:关于腹主动脉瘤修补术的指征

近日,新英格兰杂志发表了关于施行腹主动脉修补术的指征的文章,以下是该文的十大要点,值得心血管医生关注。 1是否对腹主动脉瘤施行修补术取决于评估患者接受该手术带来的风险和获益程度,如若不施行手术主动脉瘤是否会破裂,或施行手术时是否手术本身有可能威胁到患者的生命。因此需对患者进行全面评估,以权衡其风险和获益。 2 腹主动脉瘤的直径能很好地预测主动脉瘤破裂的风险,主动脉瘤破裂的风险随