Am J Resp Crit Care:快速眼动睡眠期间OSA与心血管疾病相关性分析!

2017-11-11 xing.T MedSci原创

主要发生在REM睡眠期间的严重OSA与复合心血管终点的发病率较高有关,但仅限于心血管疾病患者。

在快速眼动(REM)睡眠期间,阻塞性睡眠呼吸暂停(OSA)是一种常见的疾病。关于主要发生在REM睡眠期间的OSA是否与健康结局相关的数据十分有限。近日,呼吸内科以及重症医学领域权威杂志Am J Resp Crit Care上发表了一篇研究文章,该研究通过一个合并患有心血管疾病和未患有心血管疾病的社区样本探讨了REM睡眠期间OSA与合并心血管终点之间的关系。

研究人员将家庭多导睡眠描记术作为睡眠心脏健康研究的一部分。研究队列平均随访9.5年,研究人员对心血管事件进行了评估。只有非快速眼动(NREM)且睡眠呼吸暂停低通气指数(AHI)<5次/小时的参与者被纳入研究。复合心血管终点被定义为非致命或致命事件的发生,包括心肌梗死、冠状动脉血运重建、充血性心力衰竭和卒中。比例风险回归被用于计算复合心血管终点的调整风险比。

该样本纳入了3265例NREM-AHI<5次/小时的受试者。研究人员采用REM-AHI<5次/小时的受试者作为参照组(n=1759),对于REM-OSA严重心血管复合终点(≥30次/小时;n=180)调整后的风险比为1.35(95%可信区间为0.98-1.85)。分层分析表明,在REM睡眠期间,心血管疾病与严重OSA患者的关联最为显著,经调整后的风险比为2.56(95%可信区间为1.46-4.47)。

由此可见,主要发生在REM睡眠期间的严重OSA与复合心血管终点的发病率较高有关,但仅限于心血管疾病患者。

原始出处:

R. Nisha Aurora , et al. Obstructive Sleep Apnea During Rapid Eye Movement Sleep and Cardiovascular Disease. AM J RESP CRIT CARE 2017. https://doi.org/10.1164/rccm.201706-1112OC

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    2017-11-25 虈亣靌

    好好看下.内容丰富

    0

  4. 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content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Mon Nov 13 08:31:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260674, encodeId=02fe2606e496, content=学习了很多先进的医疗技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Sun Nov 12 07:08:31 CST 2017, time=2017-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260637, encodeId=fb6826063ebb, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Nov 12 00:20:42 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-18 虈亣靌

    谢谢分享知识

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=260637, encodeId=fb6826063ebb, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Nov 12 00:20:42 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-13 虈亣靌

    讲解的非常好,值得学习

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=260637, encodeId=fb6826063ebb, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Nov 12 00:20:42 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-13 bioon3
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  8. 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  9. 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content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Mon Nov 13 08:31:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260674, encodeId=02fe2606e496, content=学习了很多先进的医疗技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Sun Nov 12 07:08:31 CST 2017, time=2017-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260637, encodeId=fb6826063ebb, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Nov 12 00:20:42 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-12 雅文博武

    学习了很多先进的医疗技术

    0

  10. 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content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Mon Nov 13 08:31:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260674, encodeId=02fe2606e496, content=学习了很多先进的医疗技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Sun Nov 12 07:08:31 CST 2017, time=2017-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260637, encodeId=fb6826063ebb, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Nov 12 00:20:42 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-12 飛歌

    学习了很有用不错

    0

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根据在SLEEP 2016年会上发表的研究结果,体重状况和蛋白质摄入量可以预测不同睡眠阶段的长度。宾夕法尼亚大学博士后研究员Andrea M. Spaeth博士和他的同事们评估了各种能量平衡参数及其对睡眠结构的影响。根据摘要,36名健康的成年人在宾夕法尼亚大学的医院的床上睡了2个连续10小时的时间,研究人员记录多导睡眠、睡眠阶段的时间、体重、身体成分、静息能量消耗、食物和饮料的摄入量等。结果表明,