SCI REP:原发性干燥综合征患者冠心病风险增加!

2018-02-02 xing.T MedSci原创

由此可见,PSS与CHD的风险增加有关。原发性舍格伦综合征可能是CHD的独立危险因素。使用皮质类固醇和非甾体抗炎药治疗PSS患者会增加了患CHD的风险。

近日,Scientific reports 杂志上发表了一篇研究文章,该研究的目的是探讨原发性舍格伦综合征(干燥综合征)(PSS)与冠心病(CHD)之间的关系,以及探究PSS患者接受药物治疗对CHD风险的影响。

研究人员从台湾健康保险研究数据库中确定了4175例在2002至2013年期间新诊断为PSS的患者。对照者与病例比例为4:1。研究人员计算了CHD的风险和累积发生率。

校正年龄、性别、合并症和治疗药物后,PSS患者发生CHD的校正后风险比为1.17(1.03-1.34)。在PSS组发生CHD的累积发病率明显高于对照组(P<0.0001)。随着年龄的增长,PSS患者发生CHD的风险每年以4%速度增长,并且45岁到59岁的患者发生CHD的风险最高(风险比为1.464,1.195-1.794)。使用糖皮质激素(风险比为1.45,1.07-1.97)以及非甾体类抗炎药(风险比为1.31,1.05-1.65)均会增加PSS患者的CHD风险。

由此可见,PSS与CHD的风险增加有关。原发性舍格伦综合征可能是CHD的独立危险因素。使用皮质类固醇和非甾体抗炎药治疗PSS患者会增加了患CHD的风险。

原始出处:


Xue-Fen Wu,et al. Increased risk of coronary heart disease among patients with primary Sjögren’s syndrome: a nationwide population-based cohort study.Scientific reports. 2018. https://www.nature.com/articles/s41598-018-19580-y

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    2018-02-07 周周人

    学习.

    0

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    2018-02-03 lovetcm

    非甾体类抗炎药(风险比为1.31.1.05-1.65)应该减少CHD风险才合理呀.如阿司匹林

    0

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    2018-02-03 lovetcm

    背后机制是什么?

    0

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