J Pediatr Gastroenterol Nutr:补充牛乳铁蛋白不会破坏接受益生菌的早产儿的微生物群发育

2021-07-31 MedSci原创 MedSci原创

近日,研究人员评估了补充牛乳铁蛋白(bLf)是否会破坏接受预防性益生菌管理的胎龄小于31周的早产儿的肠道微生物群发育,研究结果已发表于J Pediatr Gastroenterol Nutr。

近日,研究人员评估了补充牛乳铁蛋白(bLf)是否会破坏接受预防性益生菌管理的胎龄小于31周的早产儿的肠道微生物群发育,研究结果已发表于J Pediatr Gastroenterol Nutr。

研究人员从LACUNA试验(ISRCTN66482337)中招募受试者,随机分配到每天接受益生菌补充剂或补充有100毫克bLf的益生菌与奶粉/人奶混合。每周收集入选婴儿的粪便,为期1个月,并使用V6-16S rRNA基因扩增子分析法对微生物群进行定性。

 

结果显示,在两种喂养干预措施中,婴儿的微生物群的多样性并没有随着时间的推移而增加。与不接受这些补充剂的婴儿相比,接受bLf补充剂的婴儿微生物种类更多,而且根据婴儿的胎龄,乳铁蛋白补充剂对婴儿微生物群物种丰富度具有不同的影响。分析显示,婴儿微生物群并不因干预组、出生时的胎龄段或采样时间而分离,决定样本聚类的主要因素是婴儿身份。在两个研究组的微生物群中,分类群的相对丰度或功能基因含量很少有可检测的差异。

综上,该研究结果表明,牛乳铁蛋白补充剂对接受益生菌的早产儿的微生物群组成/功能影响很小,因此,不太可能破坏微生物群的发展。

 

原始出处:

 

Kelly Grzywacz, et al., Bovine Lactoferrin Supplementation Does Not Disrupt Microbiota Development in Preterm Infants Receiving Probiotics. J Pediatr Gastroenterol Nutr. 2020 Aug;71(2):216-222. doi: 10.1097/MPG.0000000000002734.

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    2021-12-11 许安
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    2022-03-11 一叶知秋
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e5576039, createdName=ms9000001923284124, createdTime=Wed Aug 18 09:35:30 CST 2021, time=2021-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729062, encodeId=87cc1e290628a, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Nov 25 18:45:49 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347565, encodeId=b9ac134e56571, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, 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  5. 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  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e5576039, createdName=ms9000001923284124, createdTime=Wed Aug 18 09:35:30 CST 2021, time=2021-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729062, encodeId=87cc1e290628a, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Nov 25 18:45:49 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347565, encodeId=b9ac134e56571, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Aug 02 09:45:49 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367860, encodeId=1d20136e8606c, content=<a href='/topic/show?id=2cee50e22c6' target=_blank style='color:#2F92EE;'>#微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50722, encryptionId=2cee50e22c6, topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Mon Aug 02 09:45:49 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615820, encodeId=4cec1615820a7, content=<a href='/topic/show?id=09cc238250c' target=_blank style='color:#2F92EE;'>#乳铁蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23825, encryptionId=09cc238250c, topicName=乳铁蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f2c819680586, createdName=ms8543593053280928, createdTime=Mon Aug 02 09:45:49 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
    2021-08-18 ms9000001923284124

    学习了

    0

  7. 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href='/topic/show?id=09cc238250c' target=_blank style='color:#2F92EE;'>#乳铁蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23825, encryptionId=09cc238250c, topicName=乳铁蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f2c819680586, createdName=ms8543593053280928, createdTime=Mon Aug 02 09:45:49 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
    2021-11-25 feather89
  8. 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href='/topic/show?id=09cc238250c' target=_blank style='color:#2F92EE;'>#乳铁蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23825, encryptionId=09cc238250c, topicName=乳铁蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f2c819680586, createdName=ms8543593053280928, createdTime=Mon Aug 02 09:45:49 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
    2021-08-02 neurowu
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