Nature:肠道微生物菌群分析或许对于诊断肝硬化并不必要

2015-10-12 佚名 生物谷

图片来源:www.npr.org近日,发表在国际著名杂志Nature上的一项研究报告中,来自弗吉尼亚联邦大学医学院的研究人员发表了最新的数据解释了其2014年刊登在Nature上的研究结论,2014年研究者阐明了一种利用复杂的微生物群落分析来进行肝硬化的诊断,这种微生物群落是指人类集体中小型有机体的网络,包括可以增强或者减弱机体免疫系统功能的细菌和真菌等。肝硬化的主要特点是肝脏发生显著的不可逆转的


图片来源:www.npr.org

近日,发表在国际著名杂志Nature上的一项研究报告中,来自弗吉尼亚联邦大学医学院的研究人员发表了最新的数据解释了其2014年刊登在Nature上的研究结论,2014年研究者阐明了一种利用复杂的微生物群落分析来进行肝硬化的诊断,这种微生物群落是指人类集体中小型有机体的网络,包括可以增强或者减弱机体免疫系统功能的细菌和真菌等。

肝硬化的主要特点是肝脏发生显著的不可逆转的疤痕损伤,肝硬化的发生原因有很多种,比如病毒感染或者酒精滥用等,目前临床上通常利用超声波或血液检测来进行肝硬化的诊断。2014年的研究论文中,研究人员描述了一种新型但较为复杂的诊断方法,来对肝硬化患者进行诊断,但这种诊断方法并不能区分进行性或代谢失调的肝硬化患者,同时也不能区分早期阶段的肝硬化患者。

肝硬化患者往往会被分类为代偿性的或失代偿性的肝硬化,代偿性肝硬化就意味着尽管机体处于受损结疤状态机体依然可以正常工作,而失代偿肝硬化则意味着肝脏严重的疤痕组织已经开始损伤并且破坏必要的机体功能了。

研究者Bajaj说道,我们反对复杂的诊断过程,这项研究中我们提出了新的证据阐明了,失代偿肝硬化患者相比早期阶段肝硬化患者而言拥有不同的肠道微生物组;失代偿肝硬化很容易被诊断出来,但我们并不需要利用复杂的技术来对其进行诊断。

最后研究者Bajaj表示,2014年发表在Nature杂志上的研究论文的结论并不是我们完全同意的,我们必须重新分析原始的研究数据并且进行更为深入的分析;而在本文研究中我们发现当前需要并不是诊断晚期肝硬化,因为我们已经知道如何去诊断肝硬化,目前我们需要的就是开发新型技术来帮助寻找哪些肝硬化患者的疾病会随着时间而恶化。

原始出处:

Jasmohan S.et al.Decompensated cirrhosis and microbiome interpretation.Nature.Sep 16, 2015.doi:10.1038/nature14851

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    2016-08-27 李东泽

    这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。

    0

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    2015-10-17 liye789132251
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    2016-01-26 doctording1

    这篇文章有一定深度

    0

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    2016-01-26 doctording1

    是一篇不错的文章

    0

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    2015-12-28 wzf990214

    不错哦

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=105946, encodeId=811e10594668, content=这篇资讯带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Aug 27 22:32:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824610, encodeId=d9cf182461068, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Mon Jan 25 14:06:00 CST 2016, time=2016-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880834, encodeId=105d1880834d1, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Oct 17 23:06:00 CST 2015, time=2015-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59741, encodeId=281d59e4114, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 16:49:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59742, encodeId=c23759e4261, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 16:49:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49823, encodeId=41a34982377, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:29:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49824, encodeId=4b054982436, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 06:29:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49600, encodeId=67624960008, content=好学习很值得好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Dec 27 20:25:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619306, encodeId=61621619306dc, content=<a href='/topic/show?id=eb9150e29aa' target=_blank style='color:#2F92EE;'>#微生物菌群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50729, encryptionId=eb9150e29aa, topicName=微生物菌群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Wed Oct 14 01:06:00 CST 2015, time=2015-10-14, status=1, ipAttribution=)]
    2015-12-28 wzf990214

    赞一个

    0

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    2015-12-27 忠诚向上

    好学习很值得好学习

    0

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