Depress Anxiety:额-杏仁核功能连接的改变预示着儿童强迫症认知行为治疗效果

2021-06-26 MedSci原创 MedSci原创

BLA-vmPFC 通路是旨在促进患有强迫症或亚临床强迫症症状的儿童的适应性学习和恐惧消退的新疗法或预防策略的潜在目标。

强迫症(OCD)是一种致残的精神疾病,其特征是反复侵入性的想法、图像和冲动(强迫)和旨在中和由想法产生的痛苦或焦虑的重复仪式(强迫)。认知行为疗法(CBT)结合暴露和反应预防(E/RP)是儿童和成人强迫症的一线治疗,显示出儿童强迫症的疗效优于药物治疗,但在任何一种治疗方式下,许多患者往往仍存在治疗抵抗症状。因此,确定可靠的基于生物学的CBT结果预测因子对于指导临床决策和开发个性化干预措施(即精准医学)至关重要。静息态功能磁共振成像(RS-fMRI)越来越被认为是一种有希望的工具。  Depress Anxiety杂志发表一篇研究文章,利用儿童和青少年强迫症患者的纵向RS-fMRI数据,研究儿童强迫症患者特定神经回路的静息状态功能连接(RS-FC)是否发生改变,并描述CBT前后连接性症状的变化。特别地,我们关注于基底外侧杏仁核(BLA)和腹内侧前额叶皮层(vmPFC)之间的RS-FC,这可能是E/RP减轻强迫症症状的一个机制成分。 该研究采用基于种子的方法,在接受治疗的儿童和青少年强迫症患者和健康对照组(HC)的样本中检测vmPFC和BLA之间的RS-FC。还使用CLPMs检查

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1923875, encodeId=720619238e509, content=<a href='/topic/show?id=3851261084' target=_blank style='color:#2F92EE;'>#anxiety#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2610, encryptionId=3851261084, topicName=anxiety)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Thu Sep 09 06:54:44 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894223, encodeId=afad189422324, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64637, encryptionId=5e456463eee, topicName=治疗效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sat Mar 19 20:54:44 CST 2022, time=2022-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075972, encodeId=130b20e597271, content=<a href='/topic/show?id=85ca90034ae' target=_blank style='color:#2F92EE;'>#行为治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90034, encryptionId=85ca90034ae, topicName=行为治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d784426, createdName=isabellayj, createdTime=Thu Oct 14 10:54:44 CST 2021, time=2021-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709835, encodeId=cf531e09835d3, content=<a href='/topic/show?id=d6d591262e9' target=_blank style='color:#2F92EE;'>#认知行为#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91262, encryptionId=d6d591262e9, topicName=认知行为)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=250931794284, createdName=ms4468361851264128, createdTime=Thu May 12 21:54:44 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445784, encodeId=76181445e84ce, content=<a href='/topic/show?id=a343329413c' target=_blank style='color:#2F92EE;'>#功能连接#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32941, encryptionId=a343329413c, topicName=功能连接)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJciayulicXZn6VO5hXfUv98oceXTHpMayS6T4PrSPsgsN6Jt2kCyAo9tAQwf1jCiaw4y8lxZFBA5nJg/132, createdBy=5ddb5182578, createdName=showtest, createdTime=Sun Jun 27 16:54:44 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540398, encodeId=7292154039868, content=<a href='/topic/show?id=48d6614666b' target=_blank style='color:#2F92EE;'>#杏仁核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61466, encryptionId=48d6614666b, topicName=杏仁核)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53c913230719, createdName=paperyu, createdTime=Sun Jun 27 16:54:44 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977067, encodeId=62e89e706730, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210524/88cf28cf32a3433d92e50eeabcaef091/3fea35bb7b2c4c47ba6abd550b722d92.jpg, createdBy=af772348903, createdName=合格, createdTime=Sat Jun 26 14:14:34 CST 2021, time=2021-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032983, encodeId=e2e010329831a, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat Jun 26 04:54:44 CST 2021, time=2021-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047375, encodeId=2f4c104e37553, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sat Jun 26 04:54:44 CST 2021, time=2021-06-26, status=1, ipAttribution=)]
    2021-06-27 paperyu
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    2021-06-26 合格

    不错

    0

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    2021-06-26 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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    2021-06-26 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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