SCI REP:血清D-二聚体是肾活检患者血栓栓塞并发症的潜在预测因子!

2017-07-06 xing.T MedSci原创

该研究结果表明血清D-二聚体可以作为肾脏病患者血栓事件的潜在预测因子。应进一步注意这些受试者。

肾脏活检已广泛应用于临床,以确定肾脏疾病的组织学类型。为防止出血并发症,患者应在肾活检前常规停止抗凝剂治疗。然而,肾脏疾病患者易发生血栓栓塞,特别是在那些有严重低白蛋白血症的患者。

近日,Scientific reports 杂志上发表了一篇研究文章,该研究旨在探讨血清D-二聚体在肾脏活检后作为血栓事件的预测因素。400名连续就诊的肾穿刺活检患者被前瞻性地纳入2个月的随访研究。

研究人员发现受试者出血和血栓性并发症的总发生率为4%,其中包括血尿或较大的肾周血肿(2.5%,n=10)和血栓性并发症(1.5%,n=6)。与较低的血清D-二聚体(<2μg/ml)的患者相比,较高血清D-二聚体(≥2μg/ml)的患者更倾向于发生血栓性并发症(9.1% vs. 0.3%;RR为30.33;P<0.001)。二聚体与年龄呈正相关性(Rs=0.258,P<0.001)。与白蛋白呈逆相关性(Rs=-0.339,P<0.001)。综合考虑,较高血清D-二聚体患者肾活检后血栓并发症的风险增加。

该研究结果表明血清D-二聚体可以作为肾脏病患者血栓事件的潜在预测因子。应进一步注意这些受试者。

原始出处:


Xia Tan,et al. Serum D-dimer is a potential predictor for thromboembolism complications in patients with renal biopsy.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-05210-6

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    2017-12-29 hxj0117
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    2017-07-11 医艺依意

    这研究有意思吗?

    0

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Tue Jul 11 07:28:43 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390059, encodeId=1114139005977, content=<a href='/topic/show?id=2c4f82568fe' target=_blank style='color:#2F92EE;'>#肾活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82568, encryptionId=2c4f82568fe, topicName=肾活检)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C5ibuQjkOouoz6QTH7VKicSeuLlHPic9Xb56TjJaQKm9SjrBorMp1K54ze94eiaXkYQO5myZ6c0fzsMqdpyFzj67AQ/132, createdBy=28a42500049, createdName=丁鹏鹏, createdTime=Sat Jul 08 13:53:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310842, encodeId=3f8c131084255, content=<a href='/topic/show?id=b15c5628e9' target=_blank style='color:#2F92EE;'>#D-二聚体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5628, encryptionId=b15c5628e9, topicName=D-二聚体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e093393, createdName=luwei00, createdTime=Sat Jul 08 13:53:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310637, encodeId=44d8131063e12, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Sat Jul 08 13:53:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278019, encodeId=9a0f12e801979, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sat Jul 08 13:53:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219713, encodeId=ab08219e13ba, content=学习一下吧!学习一下了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sat Jul 08 05:59:22 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219703, encodeId=f9f6219e0392, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Sat Jul 08 05:20:41 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1950351, encodeId=c18619503518e, content=<a href='/topic/show?id=bfc624041dc' target=_blank style='color:#2F92EE;'>#二聚体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24041, encryptionId=bfc624041dc, topicName=二聚体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac59108, createdName=hxj0117, createdTime=Fri Dec 29 17:53:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1812009, encodeId=0113181200951, content=<a href='/topic/show?id=32e989118bd' target=_blank style='color:#2F92EE;'>#血栓栓塞并发症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89118, encryptionId=32e989118bd, topicName=血栓栓塞并发症)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 06 18:53:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757810, encodeId=17501e578102f, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun Apr 08 16:53:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220913, encodeId=6a77220913bb, content=这研究有意思吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Tue Jul 11 07:28:43 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390059, encodeId=1114139005977, content=<a href='/topic/show?id=2c4f82568fe' target=_blank style='color:#2F92EE;'>#肾活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82568, encryptionId=2c4f82568fe, topicName=肾活检)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C5ibuQjkOouoz6QTH7VKicSeuLlHPic9Xb56TjJaQKm9SjrBorMp1K54ze94eiaXkYQO5myZ6c0fzsMqdpyFzj67AQ/132, createdBy=28a42500049, createdName=丁鹏鹏, createdTime=Sat Jul 08 13:53:00 CST 2017, 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authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Sat Jul 08 13:53:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278019, encodeId=9a0f12e801979, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sat Jul 08 13:53:00 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219713, encodeId=ab08219e13ba, content=学习一下吧!学习一下了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sat Jul 08 05:59:22 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219703, encodeId=f9f6219e0392, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Sat Jul 08 05:20:41 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 smlt2008
  9. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sat Jul 08 05:59:22 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219703, encodeId=f9f6219e0392, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Sat Jul 08 05:20:41 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 ren1mw

    学习一下吧!学习一下了!

    0

  10. 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    2017-07-08 chunjianf

    学习了,谢谢分享

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