Omega-3脂肪酸与前列腺癌风险增高有关(SELECT研究)

2013-07-13 MedSci MedSci原创

   Fred Hutchinson癌症研究中心的第二大前瞻性实验证明,高血药浓度的Omega-3脂肪酸与前列腺癌患病风险增加有关。  研究结果发表在7月11日在线的《美国国家癌症研究所杂志》上,最新发现表明高血药浓度EPA、DPA和DHA——三种抗炎药物以及来源于脂肪鱼和鱼油补充剂有关新城代谢脂肪酸——与71%高分化前列腺癌的增加有关。这项研究同时发现44%低分化前列腺癌的升

   Fred Hutchinson癌症研究中心的第二大前瞻性实验证明,高血药浓度的Omega-3脂肪酸与前列腺癌患病风险增加有关。
  研究结果发表在7月11日在线的《美国国家癌症研究所杂志》上,最新发现表明高血药浓度EPA、DPA和DHA——三种抗炎药物以及来源于脂肪鱼和鱼油补充剂有关新城代谢脂肪酸——与71%高分化前列腺癌的增加有关。这项研究同时发现44%低分化前列腺癌的升高也相关,并且43%与所有前列腺癌的风险升高有关。   

  因为高分化前列腺癌增加的风险有可能是致命的,所以这些肿瘤是十分重要的。   

  在 2011年同样由Fred Hutch科学研究小组发布,有关高血药浓度的DHA与前列腺癌风险增加,以及与发育中高分化前列腺癌双倍增加风险的研究结果被于 2011年。

  “这些研究结果,预示这些脂肪酸涉及的前列腺肿瘤,并建议增加长链Omega-3脂肪酸摄取,特别是通过补充剂摄入,都应该考虑Omega-3的潜在风险,”作者写道。“我们已经发现,一旦再次使用营养补充剂,可能造成伤害,”医学博士Alan Kristal说。Kristal也同时表示,近期发表于《美国医学会》的学术分析表明,Omega-3补充剂有益于心血管疾病的疑惑。这些结合了20个研究数据的分析发现,没有降低全死因死亡率、心脏病或中风的问题。   

  “重要的是,我们已经能够重复我们从2011年的研究结果,并且我们确认深海Omega-3脂肪酸,在前列腺癌发生上的关键作用,”Theodore Brasky博士说。“然而,必须要声明的是,这些研究结果,并没有解决为什么Omega-3在前列腺癌预防中的有害作用,”他表示。   

  不同的血药浓度的Omega-3脂肪酸,在最小和最大风险研究组中,是大约2.5个百分点(3.2% vs. 5.7%),Kristal表示,这大约比每周吃两次三文鱼的影响稍大。目前研究分析,收集参与“硒和维生素E的癌症预防试验(SELECT)”研究人的数据和样本。是研究过没有显示出,来自硒摄入的益处,和维生素E的摄取与前列腺癌增加相关。

原始出处:
Brasky TM, Darke AK, Song X, Tangen CM, Goodman PJ, Thompson IM, Meyskens FL Jr, Goodman GE, Minasian LM, Parnes HL, Klein EA, Kristal AR.Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial.J Natl Cancer Inst. 2013 Jul 10

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    2014-03-11 sjq027
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2022540, encodeId=f7192022540f5, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Tue Oct 08 22:44:00 CST 2013, time=2013-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793704, encodeId=b27d1e937041e, content=<a href='/topic/show?id=19c2161119c' target=_blank style='color:#2F92EE;'>#SeLECT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16111, encryptionId=19c2161119c, topicName=SeLECT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb0b97, createdName=zhangxingru, createdTime=Sun Mar 30 15:44:00 CST 2014, time=2014-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061386, encodeId=c50a206138675, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Mar 11 10:44:00 CST 2014, time=2014-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779113, encodeId=03051e79113d1, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Thu Mar 20 21:44:00 CST 2014, time=2014-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778737, encodeId=d69e1e7873774, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Wed Mar 05 03:44:00 CST 2014, time=2014-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561551, encodeId=74a7156155120, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 14 23:44:00 CST 2013, time=2013-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567560, encodeId=ff0f156e56073, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 14 23:44:00 CST 2013, time=2013-07-14, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2022540, encodeId=f7192022540f5, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Tue Oct 08 22:44:00 CST 2013, time=2013-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793704, encodeId=b27d1e937041e, content=<a href='/topic/show?id=19c2161119c' target=_blank style='color:#2F92EE;'>#SeLECT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16111, encryptionId=19c2161119c, topicName=SeLECT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb0b97, createdName=zhangxingru, createdTime=Sun Mar 30 15:44:00 CST 2014, time=2014-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061386, encodeId=c50a206138675, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Mar 11 10:44:00 CST 2014, time=2014-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779113, encodeId=03051e79113d1, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Thu Mar 20 21:44:00 CST 2014, time=2014-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778737, encodeId=d69e1e7873774, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Wed Mar 05 03:44:00 CST 2014, time=2014-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561551, encodeId=74a7156155120, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 14 23:44:00 CST 2013, time=2013-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567560, encodeId=ff0f156e56073, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 14 23:44:00 CST 2013, time=2013-07-14, status=1, ipAttribution=)]
    2013-07-14 liuxiaona
  7. [GetPortalCommentsPageByObjectIdResponse(id=2022540, encodeId=f7192022540f5, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Tue Oct 08 22:44:00 CST 2013, time=2013-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793704, encodeId=b27d1e937041e, content=<a href='/topic/show?id=19c2161119c' target=_blank style='color:#2F92EE;'>#SeLECT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16111, encryptionId=19c2161119c, topicName=SeLECT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb0b97, createdName=zhangxingru, createdTime=Sun Mar 30 15:44:00 CST 2014, time=2014-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061386, encodeId=c50a206138675, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Mar 11 10:44:00 CST 2014, time=2014-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779113, encodeId=03051e79113d1, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Thu Mar 20 21:44:00 CST 2014, time=2014-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778737, encodeId=d69e1e7873774, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Wed Mar 05 03:44:00 CST 2014, time=2014-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561551, encodeId=74a7156155120, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 14 23:44:00 CST 2013, time=2013-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567560, encodeId=ff0f156e56073, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Jul 14 23:44:00 CST 2013, time=2013-07-14, status=1, ipAttribution=)]
    2013-07-14 liuxiaona