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世卫将JN.1单独列为需留意的新冠变异株

2023-12-20 网络 网络 发表于上海

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鉴于新冠病毒变异株JN.1在全球范围内的快速传播，世界卫生组织12月19日发布初步风险评估，将JN.1单独列为“需要留意的变异株”，但基于目前可用的证据，JN.1对全球公共卫生

鉴于新冠病毒变异株JN.1在全球范围内的快速传播，世界卫生组织12月19日发布初步风险评估，将JN.1单独列为“需要留意的变异株”，但基于目前可用的证据，JN.1对全球公共卫生构成的额外风险目前被评估为低水平。

什么是JN.1变异株？

JN.1是新冠病毒奥密克戎BA.2.86变异株的第二代亚分支，也是BA.2.86变异株中具有较强传播优势的一个亚分支。该变异株于今年8月25日在卢森堡采集的样本中首次监测到。

与上一代BA.2.86相比，JN.1具有一个额外的刺突蛋白突变L455S，可以使得JN.1能够有效逃避1类中和抗体，使其能够超越其前体BA.2.86和流行的变体XBB.1.5和XBB.1等。

正因为有了这个突变，JN.1快速占据新冠变异株的主流地位。11月21日，世卫组织将BA.2.86变异株从“需要监测的变异株”升级为“需要关注的变异株”。

国际上JN.1变异株的流行情况如何？

今年11月以来，JN.1变异株在全球流行毒株中的占比迅速增加，从11月初的约4%增长至12月初的30%左右。截至12月10日，全球至少有40个国家/地区监测到JN.1变异株。

截至11月中旬，爱尔兰、冰岛、葡萄牙、西班牙和法国等欧洲多个国家出现指数级增长，尤其在丹麦，该变异体病毒感染已经覆盖了50%人口。英国JN.1每周增长率预计为84.2%，传播速度远远超过其他已知变异株。

美国疾病控制与预防中心（CDC）19日发布预警，称新冠病毒JN.1变异株正在成为感染增长最快的病毒株，预计将导致美国约20%的2019冠状病毒（Covid-19）感染。目前，JN.1已经在美国东北部大肆蔓延，约三分之一的新感染病例很可能是由它引起的。

CDC表示，从11月下旬到12月中旬，由于人们的假期出行以及冬天的免疫力下降，美国JN.1的流行率几乎增加了一倍多。CDC还警告说，在过去4周内，因2019冠状病毒（Covid-19）住院的人数增加了51%，给医疗系统带来了更大的压力。

JN.1变异株不排除成为我国优势流行株的可能

中国疾控中心传染病管理处研究员常昭瑞12月17日在国家卫健委新闻发布会上介绍，我国新冠病毒变异株监测结果显示，目前BA.2.86变异株在我国报告序列中的占比非常低，但输入病例的序列占比自11月以来增加较快，增长趋势逐渐与全球趋同。

国家疾控局发布的科普文章也指出，虽然当前JN.1变异株在我国流行水平极低，但后续受国际流行株和输入病例影响，不排除JN.1变异株成为国内优势流行株的可能。

JN.1致病程度没有增加

美国监测数据显示，JN.1变异株近期在美国新冠病毒感染病例中占比增加，并没有发现因感染JN.1变异株后引起疾病严重程度增加的情况。我国的监测数据也显示，JN.1变异株感染者均为轻型或无症状。

北京大学生物医学前沿创新中心研究员曹云龙团队的一项研究就表明，L455S虽然显著增强了JN.1的免疫逃逸能力，但降低了其与新冠病毒受体ACE2结合的能力。美国CDC也表示，目前没有证据表明JN.1它比其他流行的变异株造成更大的公共卫生风险，也没有迹象表明它的致病严重程度增加。

深圳市第三人民医院党委副书记、院长卢洪洲表示，国内居民普遍经历了2次感染甚至3次感染，已有的研究数据表明，个体已经产生较强且广谱的针对奥密克戎不同亚突变株的中和抗体。他推测，JN.1变异株未来在国内的流行可能会在短期内造成新冠感染患者增加，从而加重医院的医疗负担，但是不会对国内正在经历的呼吸道疾病感染潮造成太大影响。

如何防控JN.1变异株？

世界卫生组织报告显示，含有XBB.1.5成份的新冠病毒疫苗仍对JN.1变异株有效。

CDC也呼吁医院更加努力地推动疫苗接种，强调在当前接种疫苗仍然为时不晚。CDC表示，2019冠状病毒（COVID-19） 的疫苗和治疗仍对JN.1有效。尽管最新的2019冠状病毒（COVID-19）加强注射是针对XBB.1.5变体而设计的，但初步研究表明它也会产生针对JN.1的抗体，尽管数量较少。与以往一样，疫苗不会完全阻止JN.1感染，但应该会降低死亡和严重疾病的可能性。

由此可见，接种新冠疫苗依然是应对JN.1变异株的有效手段。

12月以来，我国有5款新冠疫苗相继被纳入紧急使用，分别为石药集团的新冠病毒二价mRNA疫苗、神州细胞的迭代重组新冠病毒变异株S三聚体蛋白疫苗、沃森生物的沃森生物的新冠病毒变异株mRNA疫苗（Omicron XBB.1.5）、康希诺的吸入用新冠XBB.1.5变异株疫苗（5型腺病毒载体）和丽珠医药的重组新冠病毒融合蛋白二价疫苗（CHO 细胞）。

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    2023-12-25 ms1000000687639315 来自江苏省

    学习新的知识

    0

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    2023-12-25 ms2000000147841561 来自河北省

    新冠病毒。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2176992, encodeId=924721e6992a4, content=学习新的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Mon Dec 25 09:30:22 CST 2023, time=2023-12-25, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176975, encodeId=e7a821e6975d7, content=新冠病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Mon Dec 25 07:43:24 CST 2023, time=2023-12-25, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176808, encodeId=8ca821e680862, content=都戴好口罩吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sun Dec 24 10:02:58 CST 2023, time=2023-12-24, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176668, encodeId=1d3421e6668ca, content=呼吸道疾病肆虐, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sat Dec 23 11:02:35 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176704, encodeId=3d1921e67043f, content=再次学习和更新了关于新冠, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Sat Dec 23 12:30:44 CST 2023, time=2023-12-23, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176644, encodeId=36d521e66444e, content=👍👍👍👍👍👍👍👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sat Dec 23 07:04:13 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176611, encodeId=5be021e6611fd, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0d5511730, createdName=一一人, createdTime=Fri Dec 22 20:56:29 CST 2023, time=2023-12-22, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=2176586, encodeId=bd3b21e65862d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Fri Dec 22 19:15:58 CST 2023, time=2023-12-22, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176403, encodeId=684b21e640358, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Thu Dec 21 22:05:07 CST 2023, time=2023-12-21, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176437, encodeId=970a21e6437f1, content=变逸茶12, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Fri Dec 22 07:25:18 CST 2023, time=2023-12-22, status=1, ipAttribution=河北省)]
    2023-12-24 ms2000000147841561 来自河北省

    都戴好口罩吧

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2176992, encodeId=924721e6992a4, content=学习新的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Mon Dec 25 09:30:22 CST 2023, time=2023-12-25, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176975, encodeId=e7a821e6975d7, content=新冠病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Mon Dec 25 07:43:24 CST 2023, time=2023-12-25, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176808, encodeId=8ca821e680862, content=都戴好口罩吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sun Dec 24 10:02:58 CST 2023, time=2023-12-24, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176668, encodeId=1d3421e6668ca, content=呼吸道疾病肆虐, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sat Dec 23 11:02:35 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176704, encodeId=3d1921e67043f, content=再次学习和更新了关于新冠, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Sat Dec 23 12:30:44 CST 2023, time=2023-12-23, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176644, encodeId=36d521e66444e, content=👍👍👍👍👍👍👍👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sat Dec 23 07:04:13 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176611, encodeId=5be021e6611fd, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0d5511730, createdName=一一人, createdTime=Fri Dec 22 20:56:29 CST 2023, time=2023-12-22, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=2176586, encodeId=bd3b21e65862d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Fri Dec 22 19:15:58 CST 2023, time=2023-12-22, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176403, encodeId=684b21e640358, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Thu Dec 21 22:05:07 CST 2023, time=2023-12-21, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176437, encodeId=970a21e6437f1, content=变逸茶12, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Fri Dec 22 07:25:18 CST 2023, time=2023-12-22, status=1, ipAttribution=河北省)]
    2023-12-23 ms2000000147841561 来自河北省

    呼吸道疾病肆虐

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2176992, encodeId=924721e6992a4, content=学习新的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Mon Dec 25 09:30:22 CST 2023, time=2023-12-25, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176975, encodeId=e7a821e6975d7, content=新冠病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Mon Dec 25 07:43:24 CST 2023, time=2023-12-25, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176808, encodeId=8ca821e680862, content=都戴好口罩吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sun Dec 24 10:02:58 CST 2023, time=2023-12-24, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176668, encodeId=1d3421e6668ca, content=呼吸道疾病肆虐, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sat Dec 23 11:02:35 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176704, encodeId=3d1921e67043f, content=再次学习和更新了关于新冠, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Sat Dec 23 12:30:44 CST 2023, time=2023-12-23, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176644, encodeId=36d521e66444e, content=👍👍👍👍👍👍👍👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sat Dec 23 07:04:13 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176611, encodeId=5be021e6611fd, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0d5511730, createdName=一一人, createdTime=Fri Dec 22 20:56:29 CST 2023, time=2023-12-22, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=2176586, encodeId=bd3b21e65862d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Fri Dec 22 19:15:58 CST 2023, time=2023-12-22, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176403, encodeId=684b21e640358, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Thu Dec 21 22:05:07 CST 2023, time=2023-12-21, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176437, encodeId=970a21e6437f1, content=变逸茶12, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Fri Dec 22 07:25:18 CST 2023, time=2023-12-22, status=1, ipAttribution=河北省)]
    2023-12-23 ms1000000687639315 来自江苏省

    再次学习和更新了关于新冠

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2176992, encodeId=924721e6992a4, content=学习新的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Mon Dec 25 09:30:22 CST 2023, time=2023-12-25, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176975, encodeId=e7a821e6975d7, content=新冠病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Mon Dec 25 07:43:24 CST 2023, time=2023-12-25, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176808, encodeId=8ca821e680862, content=都戴好口罩吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sun Dec 24 10:02:58 CST 2023, time=2023-12-24, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176668, encodeId=1d3421e6668ca, content=呼吸道疾病肆虐, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sat Dec 23 11:02:35 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176704, encodeId=3d1921e67043f, content=再次学习和更新了关于新冠, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Sat Dec 23 12:30:44 CST 2023, time=2023-12-23, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176644, encodeId=36d521e66444e, content=👍👍👍👍👍👍👍👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sat Dec 23 07:04:13 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176611, encodeId=5be021e6611fd, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0d5511730, createdName=一一人, createdTime=Fri Dec 22 20:56:29 CST 2023, time=2023-12-22, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=2176586, encodeId=bd3b21e65862d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Fri Dec 22 19:15:58 CST 2023, time=2023-12-22, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176403, encodeId=684b21e640358, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Thu Dec 21 22:05:07 CST 2023, time=2023-12-21, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176437, encodeId=970a21e6437f1, content=变逸茶12, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Fri Dec 22 07:25:18 CST 2023, time=2023-12-22, status=1, ipAttribution=河北省)]
    2023-12-23 13013f32m56暂无昵称 来自河北省

    👍👍👍👍👍👍👍👍👍👍

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2176992, encodeId=924721e6992a4, content=学习新的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Mon Dec 25 09:30:22 CST 2023, time=2023-12-25, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176975, encodeId=e7a821e6975d7, content=新冠病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Mon Dec 25 07:43:24 CST 2023, time=2023-12-25, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176808, encodeId=8ca821e680862, content=都戴好口罩吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sun Dec 24 10:02:58 CST 2023, time=2023-12-24, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176668, encodeId=1d3421e6668ca, content=呼吸道疾病肆虐, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sat Dec 23 11:02:35 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176704, encodeId=3d1921e67043f, content=再次学习和更新了关于新冠, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Sat Dec 23 12:30:44 CST 2023, time=2023-12-23, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176644, encodeId=36d521e66444e, content=👍👍👍👍👍👍👍👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sat Dec 23 07:04:13 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176611, encodeId=5be021e6611fd, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0d5511730, createdName=一一人, createdTime=Fri Dec 22 20:56:29 CST 2023, time=2023-12-22, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=2176586, encodeId=bd3b21e65862d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Fri Dec 22 19:15:58 CST 2023, time=2023-12-22, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176403, encodeId=684b21e640358, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Thu Dec 21 22:05:07 CST 2023, time=2023-12-21, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176437, encodeId=970a21e6437f1, content=变逸茶12, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Fri Dec 22 07:25:18 CST 2023, time=2023-12-22, status=1, ipAttribution=河北省)]
    2023-12-22 一一人 来自广西

    谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2176992, encodeId=924721e6992a4, content=学习新的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Mon Dec 25 09:30:22 CST 2023, time=2023-12-25, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176975, encodeId=e7a821e6975d7, content=新冠病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Mon Dec 25 07:43:24 CST 2023, time=2023-12-25, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176808, encodeId=8ca821e680862, content=都戴好口罩吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sun Dec 24 10:02:58 CST 2023, time=2023-12-24, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176668, encodeId=1d3421e6668ca, content=呼吸道疾病肆虐, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sat Dec 23 11:02:35 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176704, encodeId=3d1921e67043f, content=再次学习和更新了关于新冠, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Sat Dec 23 12:30:44 CST 2023, time=2023-12-23, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176644, encodeId=36d521e66444e, content=👍👍👍👍👍👍👍👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sat Dec 23 07:04:13 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176611, encodeId=5be021e6611fd, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0d5511730, createdName=一一人, createdTime=Fri Dec 22 20:56:29 CST 2023, time=2023-12-22, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=2176586, encodeId=bd3b21e65862d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Fri Dec 22 19:15:58 CST 2023, time=2023-12-22, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176403, encodeId=684b21e640358, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Thu Dec 21 22:05:07 CST 2023, time=2023-12-21, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176437, encodeId=970a21e6437f1, content=变逸茶12, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Fri Dec 22 07:25:18 CST 2023, time=2023-12-22, status=1, ipAttribution=河北省)]
    2023-12-22 1dea4a7em68(暂无匿称) 来自福建省

    谢谢分享

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2176992, encodeId=924721e6992a4, content=学习新的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Mon Dec 25 09:30:22 CST 2023, time=2023-12-25, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176975, encodeId=e7a821e6975d7, content=新冠病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Mon Dec 25 07:43:24 CST 2023, time=2023-12-25, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176808, encodeId=8ca821e680862, content=都戴好口罩吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sun Dec 24 10:02:58 CST 2023, time=2023-12-24, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176668, encodeId=1d3421e6668ca, content=呼吸道疾病肆虐, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sat Dec 23 11:02:35 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176704, encodeId=3d1921e67043f, content=再次学习和更新了关于新冠, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Sat Dec 23 12:30:44 CST 2023, time=2023-12-23, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176644, encodeId=36d521e66444e, content=👍👍👍👍👍👍👍👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sat Dec 23 07:04:13 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176611, encodeId=5be021e6611fd, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0d5511730, createdName=一一人, createdTime=Fri Dec 22 20:56:29 CST 2023, time=2023-12-22, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=2176586, encodeId=bd3b21e65862d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Fri Dec 22 19:15:58 CST 2023, time=2023-12-22, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176403, encodeId=684b21e640358, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Thu Dec 21 22:05:07 CST 2023, time=2023-12-21, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176437, encodeId=970a21e6437f1, content=变逸茶12, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Fri Dec 22 07:25:18 CST 2023, time=2023-12-22, status=1, ipAttribution=河北省)]
    2023-12-21 1dea4a7em68(暂无匿称) 来自福建省

    谢谢分享

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2176992, encodeId=924721e6992a4, content=学习新的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Mon Dec 25 09:30:22 CST 2023, time=2023-12-25, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176975, encodeId=e7a821e6975d7, content=新冠病毒。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Mon Dec 25 07:43:24 CST 2023, time=2023-12-25, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176808, encodeId=8ca821e680862, content=都戴好口罩吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sun Dec 24 10:02:58 CST 2023, time=2023-12-24, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176668, encodeId=1d3421e6668ca, content=呼吸道疾病肆虐, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Sat Dec 23 11:02:35 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176704, encodeId=3d1921e67043f, content=再次学习和更新了关于新冠, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d545434460, createdName=ms1000000687639315, createdTime=Sat Dec 23 12:30:44 CST 2023, time=2023-12-23, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=2176644, encodeId=36d521e66444e, content=👍👍👍👍👍👍👍👍👍👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20c53431821, createdName=13013f32m56暂无昵称, createdTime=Sat Dec 23 07:04:13 CST 2023, time=2023-12-23, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2176611, encodeId=5be021e6611fd, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b0d5511730, createdName=一一人, createdTime=Fri Dec 22 20:56:29 CST 2023, time=2023-12-22, status=1, ipAttribution=广西), GetPortalCommentsPageByObjectIdResponse(id=2176586, encodeId=bd3b21e65862d, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Fri Dec 22 19:15:58 CST 2023, time=2023-12-22, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176403, encodeId=684b21e640358, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/23/914ab8c212b86139546fc16eed98b36f.jpg, createdBy=90821711402, createdName=1dea4a7em68(暂无匿称), createdTime=Thu Dec 21 22:05:07 CST 2023, time=2023-12-21, status=1, ipAttribution=福建省), GetPortalCommentsPageByObjectIdResponse(id=2176437, encodeId=970a21e6437f1, content=变逸茶12, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5bf26472850, createdName=ms2000000147841561, createdTime=Fri Dec 22 07:25:18 CST 2023, time=2023-12-22, status=1, ipAttribution=河北省)]
    2023-12-22 ms2000000147841561 来自河北省

    变逸茶12

    0

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