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J Tissue Eng：甲基丙烯酸明胶/乙酰透明质酸可作为软组织再生的支架

2018-01-24 MedSci MedSci原创

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体外生产制备的软组织可以为软组织缺陷提供替代治疗。本研究旨在评估甲基丙烯酸明胶/乙酰透明质酸作为软组织工程支架及其与人类脂肪干细胞（hASCs）的相互作用。将ASC掺入甲基丙烯酸酯化的明胶/透明质酸水凝胶中。使用苯基-2,4,6-三甲基苯甲酰基膦酸锂光引发剂使凝胶光致交联，并在30天的时间内分析ASCs的细胞活力和脂肪分化。另外，进行血管生成测定以评估其血管生成潜力。结果显示，24小时后，ASCs

体外生产制备的软组织可以为软组织缺陷提供替代治疗。本研究旨在评估甲基丙烯酸明胶/乙酰透明质酸作为软组织工程支架及其与人类脂肪干细胞（hASCs）的相互作用。

将ASC掺入甲基丙烯酸酯化的明胶/透明质酸水凝胶中。使用苯基-2,4,6-三甲基苯甲酰基膦酸锂光引发剂使凝胶光致交联，并在30天的时间内分析ASCs的细胞活力和脂肪分化。另外，进行血管生成测定以评估其血管生成潜力。

结果显示，24小时后，ASCs显示复合水凝胶的生存力增加。这些结果在21天的培养中一致。通过诱导成脂分化，在培养7天后观察到成熟的脂肪细胞，其数目及脂肪酸结合蛋白4和脂连蛋白的表达在第28天明显增加。

综上所述，该研究结果表明，本研究所制备的支架有希望作为脂肪组织工程的基石，并允许ASCs的长期存活、增殖和分化。

原始出处：

Kessler L, Gehrke S, et al., Methacrylated gelatin/hyaluronan-based hydrogels for soft tissue engineering. J Tissue Eng. 2017 Dec 21;8:2041731417744157. doi: 10.1177/2041731417744157. eCollection 2017 Jan-Dec.

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    2018-04-02 zhouqu_8

    #Eng#

    0

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    2018-10-23 zhaojie88

    #Tissue#

    0

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    2018-01-26 kalseyzl

    #透明质酸#

    0

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    2018-01-26 qilu_qi

    #软组织#

    0

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    2018-01-26 sunyl13

    #组织再生#

    0