J ALZHEIMERS DIS:奶酪和葡萄酒或可预防认知功能下降

2020-12-11 MedSci原创 MedSci原创

俗话说,民以食为天。可见,饮食在人们的生活中占有十分重要的位置。近日,科学家发现,人们所吃的食物可能会在以后几年直接影响机体的认知敏锐度。

俗话说,民以食为天。可见,饮食在人们的生活中占有十分重要的位置。近日,科学家发现,人们所吃的食物可能会在以后几年直接影响机体的认知敏锐度。该研究发表在Journal of Alzheimer's Disease杂志上。

研究人员基于英国生物银行(UK Biobank)生物医学数据库对年龄在46至77岁1787名参与者进行数据分析,评估食物与晚年认知敏锐度的关系。根据食物频率问卷(FFQ)中49种全食物的自我报告摄入量,对10年流体智能测试(FIT)轨迹进行建模并回归到总饮食中。同时,参与者通过基线和两次随访评估回答了有关其食物和酒精消耗的问题。

奶酪摄入频率与FH和APOE4+的关联

酒精摄入频率与FH和APOE4+的关联

盐的摄入频率与FH和APOE4+的关联

结果发现,随着时间的推移,每天摄入奶酪FIT评分会更高 (FH-: β= 0.207, p < 0.001; ɛ4–: β= 0.073, p = 0.008; ɛ4+: β= 0.162, p = 0.001)。每天摄入酒精似乎同样有益(ɛ4+: β= 0.101, p = 0.022) ,尤其红酒还具有保护作用 (FH+: β= 0.100, p = 0.014; ɛ4–: β= 0.59, p = 0.039)。每周食用羊肉与改善结局相关(FH-: β= 0.066, p = 0.008; ɛ4+: β= 0.097, p = 0.044)。在高危人群中,添加盐与性能下降相关(FH+: β= –0.114, p = 0.004; ɛ4+: β= –0.121, p = 0.009)。

综上,修改膳食计划有助于最大限度地减少认知能力下降。随着时间的推移,奶酪已被证明是最有效的食品,可防止与年龄有关的认知问题,甚至到生命后期。每日饮用酒精,尤其是红酒,与认知功能的改善有关。另外,每周食用羊肉,而不是其他红肉,可以改善长期的认知能力。当然,众所周知,过量食用盐影响身体健康,阿尔茨海默症高危人群更应该注意摄入量,以免随着时间的推移出现认知问题。

原始出处

Brandon S. Klinedinst et al, Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study, Journal of Alzheimer's Disease  2020 

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    2021-01-21 zhaojie88
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    2021-08-30 anminleiryan
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  5. 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  6. 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  7. 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time=2020-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907313, encodeId=9d1e90e3130d, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Dec 12 15:14:44 CST 2020, time=2020-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907286, encodeId=fabb90e28694, content=红酒是个有争论的话题,柳叶刀说最好滴酒不沾,这篇研究说适量的红酒有益于认知健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sat Dec 12 12:57:20 CST 2020, time=2020-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907155, encodeId=499390e155a3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/B0E2439972CE8FFE31DAD756C2A72E8F/100, createdBy=d7fe2049696, createdName=Belle姑娘, createdTime=Fri Dec 11 21:16:01 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-12 rayms

    看来要多吃奶酪?🧀️

    0

  8. 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createdBy=3a345397082, createdName=Jessica, createdTime=Sat Dec 12 12:57:20 CST 2020, time=2020-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907155, encodeId=499390e155a3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/B0E2439972CE8FFE31DAD756C2A72E8F/100, createdBy=d7fe2049696, createdName=Belle姑娘, createdTime=Fri Dec 11 21:16:01 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-12 医鸣惊人

    认真学习了

    0

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createdBy=3a345397082, createdName=Jessica, createdTime=Sat Dec 12 12:57:20 CST 2020, time=2020-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907155, encodeId=499390e155a3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/B0E2439972CE8FFE31DAD756C2A72E8F/100, createdBy=d7fe2049696, createdName=Belle姑娘, createdTime=Fri Dec 11 21:16:01 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-12 Jessica

    红酒是个有争论的话题,柳叶刀说最好滴酒不沾,这篇研究说适量的红酒有益于认知健康。

    0

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    2020-12-11 Belle姑娘

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