Liver Int:妊娠前肝酶水平和子痫前期风险:以人群为基础的队列研究

2018-05-14 MedSci MedSci原创

妊娠前异常丙氨酸氨基转移酶水平与子痫前期的发生有关。还需要进一步的研究来评估妊娠前对肝功能的早期干预是否能降低子痫前期的风险。

研究背景和目的:先兆子痫是一种严重的多系统疾病,可导致孕产妇和新生儿不良结局。然而,人们对这种疾病的早期标记知之甚少。本研究的目的是探讨妊娠前肝功能与子痫前期发展的关系。

研究方法:本研究纳入192 571例韩国妇女,在2008年1月1号至2014年12月31号期间,这些妇女首次生产。并且在分娩前1-2年通过国家健康保险公司进行了全国健康检查。

研究结果:3973例(2.0%)女性发生了子痫前期。妊娠前,肝酶水平异常的女性,相比正常肝酶水平的女性,患子痫前期发生的风险增高。在调整了年龄、高血压家族史,乙型肝炎病毒载体状态、吸烟、饮酒状况,孕前体重指数和血压等因素后,多变量分析表明,在怀孕前,丙氨酸转氨酶水平异常的女性相比丙氨酸转氨酶水平正常的女性,患子痫前期的风险,增加了1.21倍。前妊娠的谷氨酰基转移酶和天冬氨酸转氨酶水平与子痫前期的发病风险无关。

研究结论:妊娠前异常丙氨酸氨基转移酶水平与子痫前期的发生有关。还需要进一步的研究来评估妊娠前对肝功能的早期干预是否能降低子痫前期的风险。

原始出处:

Cho GJ, Kim HY, Park JH, et al. Prepregnancy liver enzyme levels and risk of preeclampsia in a subsequent pregnancy: A population-based cohort study.Liver Int, 2018, 38(5), 949-954.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1946745, encodeId=58851946e4567, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Tue Apr 16 03:49:00 CST 2019, time=2019-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366559, encodeId=64b2136655954, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed May 16 11:49:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315130, encodeId=bb0b315130c9, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 14 22:37:19 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-16 yahu
  3. [GetPortalCommentsPageByObjectIdResponse(id=1946745, encodeId=58851946e4567, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Tue Apr 16 03:49:00 CST 2019, time=2019-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366559, encodeId=64b2136655954, content=<a href='/topic/show?id=097a452219b' target=_blank style='color:#2F92EE;'>#子痫前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45221, encryptionId=097a452219b, topicName=子痫前期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Wed May 16 11:49:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315130, encodeId=bb0b315130c9, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 14 22:37:19 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 131****2916

    不错的文章值得推荐

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