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Polymers:甲基丙烯酸化明胶掺杂生物活性玻璃可用于骨缺损的再生

2019-05-19 不详 网络

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最近组织工程领域对Cryogels产生了兴趣，因为它们固有地具有相互连接的大孔结构。甲基化明胶（GelMA）被认为适用于支架冷冻凝胶制造，是一种改良形式的明胶，因其能够保留细胞粘附位点而受到重视。生物玻璃纳米粒子由于其骨诱导和骨传导行为而在该领域也引起了关注。在这里，我们制备具有不同浓度的生物玻璃纳米粒子的甲基丙烯酸化明胶冷冻凝胶，以研究其骨再生的潜力。在体外测试期间，冷冻凝胶中生物玻璃浓度的增加

最近组织工程领域对Cryogels产生了兴趣，因为它们固有地具有相互连接的大孔结构。甲基化明胶（GelMA）被认为适用于支架冷冻凝胶制造，是一种改良形式的明胶，因其能够保留细胞粘附位点而受到重视。生物玻璃纳米粒子由于其骨诱导和骨传导行为而在该领域也引起了关注。

在这里，我们制备具有不同浓度的生物玻璃纳米粒子的甲基丙烯酸化明胶冷冻凝胶，以研究其骨再生的潜力。在体外测试期间，冷冻凝胶中生物玻璃浓度的增加改善了水凝胶的机械性质，增强了间充质细胞的成骨分化。微CT和组织学研究显示，在小鼠颅骨缺损模型中，与其他测试组相比，结合在GelMA冷冻凝胶中的最高浓度的生物玻璃纳米颗粒（2.5w/w％）诱导最多的骨形成。

总之，该研究结果突出了结合在GelMA冷凝胶中用于骨再生的生物玻璃纳米颗粒的潜力。

原始出处：

Kwon S, Lee SS, et al., Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects. Polymers (Basel). 2018 Aug 14;10(8). pii: E914. doi: 10.3390/polym10080914.

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    2019-12-07 fyxzlh

    #生物活性玻璃#

    0

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    2020-01-15 anminleiryan

    #ERS#

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    2019-05-29 zhouqu_8

    #polymer#

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    2019-05-21 ms49895894946433513521

    #MERS#

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    2019-05-21 lfcmxl

    #骨缺损#

    0