NEJM:舌鳞状细胞癌-案例报道

2016-06-23 MedSci MedSci原创

女性,73岁,出现舌头右缘溃疡、白斑,以及吃东西时出现疼痛1年余。

女性,73岁,出现舌头右缘溃疡、白斑,以及吃东西时出现疼痛1年余。

 
既往无抽烟和饮酒史。

颈部淋巴结检查未触及肿大。口腔检查可见舌头浅表有一界限清楚,大小为7mmX3mm的溃疡。另外,在溃疡部位的边缘有硬化的现象,在舌头右缘的下边界有多处红白的斑点(如图A)。

硬结上缘切开取样活检显示浸润性鳞状细胞癌(如图B;苏木精伊红染色)。

斑点部位切开取样活检显示染色加深和多形性的基底上皮层细胞和“萌芽”结构,被视为轻度不典型增生(如图C;苏木精伊红染色)。

计算机断层扫描证实无颈部淋巴结受累。

最后,病人接受了癌变部位广泛性切除,在术后的12个月中,病人没有出现复发的现象。

目前,晚期的舌鳞状细胞癌患者,术后5年生存率仅仅保持在50%左右。在临床上,通常以取样活检为诊断的辅助手段,当活检结果显示细胞形状或结构改变时,高度怀疑癌变的可能。 

原始出处:

Rui P.P. Albuquerque, D.D.S., Ph.D., and Andrea Richards, B.D.S., F.D.S. (Oral Med.) Squamous-Cell Carcinoma of the TongueN Engl J Med 2016; 374:e32June 23, 2016


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  3. [GetPortalCommentsPageByObjectIdResponse(id=1810916, encodeId=011d18109163c, content=<a href='/topic/show?id=cb34865e422' target=_blank style='color:#2F92EE;'>#舌鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86574, encryptionId=cb34865e422, topicName=舌鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ca5383, createdName=bbjsj_1979, createdTime=Mon Apr 17 01:09:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978437, encodeId=1d5819e84373a, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Aug 10 22:09:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144937, encodeId=ff7b14493ede, content=好文章,受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Oct 11 18:40:33 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124604, encodeId=4006124604c6, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 10:55:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=123875, encodeId=951d1238e5d1, content=赞了!深度好文。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Sep 12 19:11:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92052, encodeId=15c09205298, content=舌鳞癌,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Tue Jul 05 21:53:00 CST 2016, time=2016-07-05, status=1, ipAttribution=)]
    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2016-09-12 ylzr123

    赞了!深度好文。

    0

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    2016-07-05 oo902

    舌鳞癌,学习了

    0

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