Rheumatology:系统性红斑狼疮:世界发病率和流行率

2017-11-13 吴星 环球医学编译

系统性红斑狼疮(SLE)是常见的风湿免疫性疾病之一,临床表现众多。2017年11月,发表在《Rheumatology》的一项流行病学研究的系统评价调查了SLE的世界发病率和流行率,以及不同年龄、性别、种族和时期的变化趋势。

系统性红斑狼疮(SLE)是常见的风湿免疫性疾病之一,临床表现众多。2017年11月,发表在《Rheumatology》的一项流行病学研究的系统评价调查了SLE的世界发病率和流行率,以及不同年龄、性别、种族和时期的变化趋势。

目的:评价SLE的世界发病率和流行率,以及不同年龄、性别、种族和时期的变化趋势。

方法:2013年8月,使用医学主题词和关键词检索,对MEDLINE和EMBASE搜索引擎中SLE联合发病率、流行率和流行病学进行相关系统检索,2016年9月更新。收集作者、期刊、发表年份、国家、地区、病例-调查方法、研究期限、发病或流行病例数、发病率(每100000人-年)或流行率(每100000人),以及年龄、性别或特定种族的发病率或流行率。

结果:SLE发病率和流行率的最大估算值为北美[分别为23.2/100000人-年(95% CI:23.4~24.0)和241/100000人(95% CI:130~352)]。非洲和乌克兰的SLE报告发病率最低(0.3/100000人-年),澳大利亚北部地区(847人的样本中0例)流行率最低。每个年龄段和种族组的女性比男性更频繁受到影响。中年人的发病率达到峰值,男性的发病顶峰较晚。黑种人的SLE发病率和流行率最高,而白种人的发病率和流行率最低。SLE似乎有随着时间的推移而增加的趋势。

结论:SLE发病率和流行率的世界差异因年龄、性别、种族和时期而不同。基因和环境风险因素相关进一步的研究或许能解释这些差异。需要对非洲进行更多流行病学的研究。

原始出处:

Frances Rees,et al.,The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies.Rheumatology.Volume 56, Issue 11, 1 November 2017, Pages 1945–1961.

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    2018-03-24 lixiaol
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    2017-11-15 zhouqu_8
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    2017-11-13 1e0f8808m18(暂无匿称)

    系统性红斑狼疮流行病学研究.

    0

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