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SCI REP：实体肿瘤中CD146分子的预后价值！

2017-06-26 xing.T MedSci原创

实体肿瘤CD146预后价值
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总之，这些结果表明CD146高表达与肿瘤预后不良相关。CD146可能是一个有价值的预后生物标志物；然而，CD146是否能作为人类实体肿瘤治疗的潜在靶点有待进一步研究。

CD146，也被称为黑色素瘤细胞粘附分子，被初步确定为黑色素瘤进展和转移的一个标志。最近，许多临床研究表明过表达CD146可以预测预后差的肿瘤，然而，结果并不明确，部分原因是由于研究纳入的患者样本量较少。

近日，Scientific reports 杂志上发表了一篇荟萃分析文章，研究人员利用所有旨在明确实体肿瘤CD146表达预后价值的临床研究。研究人员通过检索PubMed、Web of Science和EMBASE数据库确定了相关文献。

在这项荟萃分析中，12个涉及2694名参与者的研究被纳入分析，研究人员得出结论表明CD146的表达与所有终点：总生存期（OS）[风险比（HR）为2.496，95%可信区间（95%CI）为2.115-2.946]和至疾病进展的时间（TTP）（HR为2.445，95%CI为1.975-3.027）之间存在相关性。此外，亚组分析显示在蒙古患者、白人患者以及肺癌和消化系统癌症患者中CD146过表达和结局终点（OS和TTP）之间存在显著的相关性。

总之，这些结果表明CD146高表达与肿瘤预后不良相关。CD146可能是一个有价值的预后生物标志物；然而，CD146是否能作为人类实体肿瘤治疗的潜在靶点有待进一步研究。

原始出处：

Ping Zeng,et al. Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-01061-3

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    2018-05-01 一叶知秋

    #CD14#

    0

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    2017-12-14 liuyong2980

    #CD146#

    0

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    2017-06-28 weiz

    #实体肿瘤#

    0

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    2017-06-28 paperyu

    #预后价值#

    0

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    2017-06-27 luominglian113

    学习了，谢谢分享

    0

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    2017-06-27 1e20390em99(暂无匿称)

    值得学习分享

    0

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    2017-06-26 清风拂面

    学习受益匪浅谢谢

    0

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    2017-06-26 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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